PAIN MANAGEMENT BY A COMBINATION OF CARBAMAZEPINE, HALOPERIDOL AND TRAMADOL

Aim: To investigate the effectiveness of haloperidol, carbamazepine and tramadol in the treatment of pain in patients burned during the first seven days of hospitalization.

Patients and methods: 30 patients with burns (12 to 45 years old) admitted to the burn unit of Jinnah Hospital Lahore. In our study, haloperidol (0.05-0.15 mg / kg orally once daily) and tramadol (300 mg to 400 mg continued) and carbamazepine (administered orally at a dose of 100-200 mg twice daily) for 12 hours) was given. During the study, the pain was monitored by using a pain scale for adults and children, and behavior of patients was monitored by using an observational pain assessment scale. Vital parameters like pulse rate, systolic and diastolic blood pressure, duration of sleep for each patient were recorded on the first day of treatment with these drugs up till the seventh day.

Results: Systolic and diastolic blood pressure dropped (95% CI: 9-21 mmHg, respectively; 4-13 mmHg), respectively, and the heart rate dropped (95% CI: 25 to 37 b / min); sleep duration increased to 6-7 hours a day in 19 patients (95% CI: 0.45-0.81). The median total pain score of 30 burn patients decreased from 9 to 1 in seven days; and 18 of 30 patients (95% CI: 0.4-0.75) became more calm, cooperative, relaxed, normal tones, without crying and no negative reaction to touching the wound.

Conclusion: The combination of tramadol, oral infusion of haloperidol and oral carbamazepine effectively reduces pain in burn patients.

Key words: tramadol, haloperidol, carbamazepine, burn patients.