Etanercept induced Bullous pemphigoid skin lesion in rheumatoid arthritis: A case report

Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine produced predominantly by activated macrophages, and involved in the up-regulation of inflammatory reactions, and plays a pivotal role in the pathogenesis of rheumatoid arthritis and some other autoimmune disorders. Since their introduction anti-TNF-α agents have been revolutionized the treatment of these disorders. However, some adverse events such as skin reaction, hypersensitivity, infection, reactivation of tuberculosis, and various autoimmune diseases can occur in patients using these agents. In this report, we present a female case who was diagnosed as bullous pemphigoid while receiving etanercept for treatment of rheumatoid arthritis.