Preprint Open Access

Instantaneous In Vivo Imaging of Acute Myocardial Infarct by NIR‐II Luminescent Nanodots

Sergio Mateos; José Lifante; Chunyan Li; Erving C. Ximendes; Tamara Muñoz‐Ortiz; Jingke Yao; María de la Fuente‐Fernández; Ángel Luis García Villalón; Miriam Granado; Irene Zabala Gutierrez; Jorge Rubio‐Retama; Daniel Jaque; Dirk H. Ortgies; Nuria Fernández

Fast and precise localization of ischemic tissues in the myocardium after an acute myocardial infarct is being required by clinicians as the first step towards accurate and efficient treatment. Nowadays, diagnosis of a heart attack at early times is based on biochemical blood analysis (detection of cardiac enzymes) or by ultrasound-assisted imaging. Alternative approaches are investigated to overcome the limitations of these classical techniques (time-consuming procedures or low spatial resolution). As occurs in many other fields of biomedicine, cardiological preclinical imaging can also benefit from the fast development of nanotechnologies. Indeed, bio-functionalized near-infrared-emitting nanoparticles are herein used for in vivo imaging of the heart after an acute myocardial infarct. Taking advantage of the superior acquisition speed of near-infrared fluorescence imaging, and of the efficient selective targeting of our near-infrared-emitting nanoparticles, in vivo images of the infarcted heart were obtained only a few minutes after the acute infarct event. This work opens the avenue towards cost-effective, fast and accurate in vivo imaging of ischemic myocardium tissues after an acute infarct.

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