Planned intervention: On Wednesday April 3rd 05:30 UTC Zenodo will be unavailable for up to 2-10 minutes to perform a storage cluster upgrade.
Published July 24, 2019 | Version 1
Dataset Open

Urbilaterian origin and evolution of sNPF-type neuropeptide signalling

  • 1. Queen Mary university of london
  • 2. School of Life Sciences and Proteomics Research Technology Platform
  • 3. Cancer Genetics Unit, Institut Curie, Paris

Description

Physiology and behaviour are controlled by neuropeptide signalling systems comprising peptide ligands and cognate receptors. Molecular phylogenetics combined with experimental identification of neuropeptide-receptor pairs has revealed that many neuropeptide signalling systems originated in the urbilaterian common ancestor of protostomes and deuterostomes. Neuropeptide-Y/neuropeptide-F (NPY/NPF)-type signalling is one such example, whereas NPY/NPF-related short-NPF (sNPF)-type signalling has hitherto only been identified in protostomes. Here we report the discovery of a neuropeptide (pQDRSKAMQAERTGQLRRLNPRF-NH2) that is the ligand for an sNPF-type receptor in a deuterostome, the starfish Asterias rubens (Phylum Echinodermata). Informed by phylogenetic analysis of sequence data, we conclude that the paralogous NPY/NPF-type and sNPF-type signalling systems originated in Urbilateria but NPY/NPF-type signalling was lost in echinoderms. Furthermore, we present evidence that sNPF-type peptides are orthologs of vertebrate prolactin-releasing peptides. Our findings demonstrate the importance of experimental studies on echinoderms for reconstructing the evolutionary history of neuropeptide signalling systems.

Notes

This is the data used to produce the tree presented in figure 4

Files

PhylogenyRawTree.pdf

Files (79.4 kB)

Name Size Download all
md5:f707e6be0bc2dcc0b6eb47496487a8d8
6.2 kB Preview Download
md5:5a36a5478109a931cc6b07a3c8b36541
45.6 kB Download
md5:d4861c9c99a8cdf7e8a0c56ff4de6938
27.6 kB Download