Published February 28, 2020 | Version v1
Journal article Open

Methodical approaches of estimation of probiotics` quality and rational principles of their usage in clinical practice

Creators

  • 1. D. K. Zabolotny Institute of Microbiology and Virology of National Academy of Sciences of Ukraine
  • 2. Educational Scientific Center "Institute of Biology and Medicine" Taras Shevchenko National University of Kyiv

Description

Recently probiotics have been started to be commonly used as a subsidiary therapy during many illnesses, such as intestinal and urogenital infections, diseases of the gastrointestinal and respiratory tract, also joints and connective tissue lesions, some cancers, allergies, dermatological and dental diseases. However, there are still no summary guidelines for selection and estimation of probiotic strains for different clinical cases. Thus, we have made a general conclusion of estimation of probiotics` quality and development of rational principles of probiotic therapy usage in clinical practice during the treatment of patients with the most common diseases and for their prevention. There are described key principles of implementation of step-by-step estimation of probiotic culture quality in foodstuff according to regulations of World Health Organization, European Union, Ukraine and other countries. The requirements are presented for the evaluation of safety of probiotic cultures, which include testing of their in vitro and in vivo activity in different experimental models, as well as a study of their therapeutic efficacy in clinical practice in the treatment of patients and in long periods after probiotic therapy. Also there are some evidences of possible side effects, risks or low efficiency that depends on individual characteristics of the gut microbiota quantitative and qualitative composition of each patient and stage, heaviness of clinical course of each specific disease. That`s why it is very important to take all circumstances of patients` status into account and collect all previous stored knowledge of probiotics` usage

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References

  • Shirobokov, V. P., Shirobokov, V. P., Iankovskii, D. S., Dyment, G. S. (2010). Mikrobnaia ekologiia cheloveka s tsvetnym atlasom. Kyiv: Chervona Ruta-Turs, 340.
  • Williams, N. T. (2010). Probiotics. American Journal of Health-System Pharmacy, 67 (6), 449–458. doi: http://doi.org/10.2146/ajhp090168
  • Halloran, K., Underwood, M. A. (2019). Probiotic mechanisms of action. Early Human Development, 135, 58–65. doi: http://doi.org/10.1016/j.earlhumdev.2019.05.010
  • Nichols, R. G., Peters, J. M., Patterson, A. D. (2019). Interplay Between the Host, the Human Microbiome, and Drug Metabolism. Human Genomics, 13 (1). doi: http://doi.org/10.1186/s40246-019-0211-9
  • Azad, M. A. K., Sarker, M., Wan, D. (2018). Immunomodulatory Effects of Probiotics on Cytokine Profiles. BioMed Research International, 2018, 1–10. doi: http://doi.org/10.1155/2018/8063647
  • Falagas, M. E., Betsi, G. I., Tokas, T., Athanasiou, S. (2006). Probiotics for prevention of recurrent urinary tract infections in women: a review of the evidence from microbiological and clinical studies. Drugs, 66 (9), 1253–1261. doi: http://doi.org/10.2165/00003495-200666090-00007
  • Di Cerbo, A., Palmieri, B., Aponte, M., Morales-Medina, J. C., Iannitti, T. (2015). Mechanisms and therapeutic effectiveness of lactobacilli. Journal of Clinical Pathology, 69 (3), 187–203. doi: http://doi.org/10.1136/jclinpath-2015-202976
  • Kasińska, M. A., Drzewoski, J. (2015). Effectiveness of probiotics in type 2 diabetes: a meta-analysis. Polish Archives of Internal Medicine, 125 (11), 803–813. doi: http://doi.org/10.20452/pamw.3156
  • Hendijani, F., Akbari, V. (2018). Probiotic supplementation for management of cardiovascular risk factors in adults with type II diabetes: A systematic review and meta-analysis. Clinical Nutrition, 37 (2), 532–541. doi: http://doi.org/10.1016/j.clnu.2017.02.015
  • Didari, T., Mozaffari, S., Nikfar, S., Abdollahi, M. (2015). Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis. World Journal of Gastroenterology, 21 (10), 3072–3084. doi: http://doi.org/10.3748/wjg.v21.i10.3072
  • Wang, F., Feng, J., Chen, P., Liu, X., Ma, M., Zhou, R. et. al. (2017). Probiotics in Helicobacter pylori eradication therapy: Systematic review and network meta-analysis. Clinics and Research in Hepatology and Gastroenterology, 41 (4), 466–475. doi: http://doi.org/10.1016/j.clinre.2017.04.004
  • Huang, R., Wang, K., Hu, J. (2016). Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 8 (8), 483. doi: http://doi.org/10.3390/nu8080483
  • Chang, Y.-S., Trivedi, M. K., Jha, A., Lin, Y.-F., Dimaano, L., García-Romero, M. T. (2016). Synbiotics for Prevention and Treatment of Atopic Dermatitis: A Meta-analysis of Randomized Clinical Trials. JAMA Pediatrics, 170 (3), 236–242. doi: http://doi.org/10.1001/jamapediatrics.2015.3943
  • Miller, L. E., Lehtoranta, L., Lehtinen, M. J. (2019). Short-term probiotic supplementation enhances cellular immune function in healthy elderly: systematic review and meta-analysis of controlled studies. Nutrition Research, 64, 1–8. doi: http://doi.org/10.1016/j.nutres.2018.12.011
  • Kasatpibal, N., Whitney, J. D., Saokaew, S., Kengkla, K., Heitkemper, M. M., Apisarnthanarak, A. (2017). Effectiveness of Probiotic, Prebiotic, and Synbiotic Therapies in Reducing Postoperative Complications: A Systematic Review and Network Meta-analysis. Clinical Infectious Diseases, 64 (suppl_2), S153–S160. doi: http://doi.org/10.1093/cid/cix114
  • Singhi, S. C., Kumar, S. (2016). Probiotics in critically ill children. F1000Research, 5, 407. doi: http://doi.org/10.12688/f1000research.7630.1
  • Mantegazza, C., Molinari, P., D'Auria, E., Sonnino, M., Morelli, L., Zuccotti, G. V. (2018). Probiotics and antibiotic-associated diarrhea in children: A review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment. Pharmacological Research, 128, 63–72. doi: http://doi.org/10.1016/j.phrs.2017.08.001
  • Hooijmans, C. R., de Vries, R. B. M., Rovers, M. M., Gooszen, H. G., Ritskes-Hoitinga, M. (2012). The Effects of Probiotic Supplementation on Experimental Acute Pancreatitis: A Systematic Review and Meta-Analysis. PLoS ONE, 7 (11), e48811. doi: http://doi.org/10.1371/journal.pone.0048811
  • Athalye-Jape, G., Rao, S., Patole, S. (2017). Effects of probiotics on experimental necrotizing enterocolitis: a systematic review and meta-analysis. Pediatric Research, 83 (1), 16–22. doi: http://doi.org/10.1038/pr.2017.218
  • Million, M., Angelakis, E., Paul, M., Armougom, F., Leibovici, L., Raoult, D. (2012). Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals. Microbial Pathogenesis, 53 (2), 100–108. doi: http://doi.org/10.1016/j.micpath.2012.05.007
  • Mokrozub, V. V., Lazarenko, L. M., Babenko, L. P. (2013). Antistaphylococcal action of lacto- and bifidobacteria and interleukine-2. Mikrobiological Journal, 75 (6), 17–21.
  • Suez, J., Zmora, N., Zilberman-Schapira, G., Mor, U., Dori-Bachash, M., Bashiardes, S. et. al. (2018). Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT. Cell, 174 (6), 1406–1423. doi: http://doi.org/10.1016/j.cell.2018.08.047
  • Zhong, C., Qu, C., Wang, B., Liang, S., Zeng, B. (2017). Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth: A Meta-Analysis and Systematic Review of Current Evidence. Journal of Clinical Gastroenterology, 51 (4), 300–311. doi: http://doi.org/10.1097/mcg.0000000000000814
  • Wojtyniak, K., Szajewska, H. (2017). Systematic review: probiotics for functional constipation in children. European Journal of Pediatrics, 176 (9), 1155–1162. doi: http://doi.org/10.1007/s00431-017-2972-2
  • Ng, Q. X., Soh, A. Y. S., Venkatanarayanan, N., Ho, C. Y. X., Lim, D. Y., Yeo, W.-S. (2019). A Systematic Review of the Effect of Probiotic Supplementation on Schizophrenia Symptoms. Neuropsychobiology, 78 (1), 1–6. doi: http://doi.org/10.1159/000498862
  • Bo, L., Li, J., Tao, T., Bai, Y., Ye, X., Hotchkiss, R. S. et. al. (2014). Probiotics for preventing ventilator-associated pneumonia. Cochrane database of systematic reviews, 10 (10), 1465–1858. doi: http://doi.org/10.1002/14651858.cd009066.pub2
  • Oliveira, L. V. N. de, Bastos, R. W., Ribeiro, N. de Q., Costa, M. C., Acurcio, L. B., Rocha, K. M. et. al. (2017). In vivo probiotic and antimicrobial photodynamic therapy as alternative therapies against cryptococcosis are ineffective. Veterinary Microbiology, 211, 169–173. doi: http://doi.org/10.1016/j.vetmic.2017.08.015
  • Shentsova, M. A., Surmasheva, O. V. (2014). Probiotic preparations, their quality and safety: current state (part II). Dovkillia i zdorovia, 1, 64–69.
  • Timmerman, H. M., Niers, L. E. M., Ridwan, B. U., Koning, C. J. M., Mulder, L., Akkermans, L. M. A. et. al. (2007). Design of a multispecies probiotic mixture to prevent infectious complications in critically ill patients. Clinical Nutrition, 26 (4), 450–459. doi: http://doi.org/10.1016/j.clnu.2007.04.008
  • Zmora, N., Zilberman-Schapira, G., Suez, J., Mor, U., Dori-Bachash, M., Bashiardes, S. et. al. (2018). Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features. Cell, 174 (6), 1388–1405. doi: http://doi.org/10.1016/j.cell.2018.08.041
  • Salminen, S., von Wright, A., Morelli, L., Marteau, P., Brassart, D., de Vos, W. M. (1998). Demonstration of safety of probiotics – a review. International Journal of Food Microbiology, 44 (1-2), 93–106. doi: http://doi.org/10.1016/s0168-1605(98)00128-7
  • Marteau, P., Seksik, P., Jian, R. (2002). Probiotics and health: new facts and ideas. Current Opinion in Biotechnology, 13 (5), 486–489. doi: http://doi.org/10.1016/s0958-1669(02)00368-3
  • Snydman, D. R. (2008). The Safety of Probiotics. Clinical Infectious Diseases, 46 (s2), S104–S111. doi: http://doi.org/10.1086/523331
  • Mayes, T., Gottschlich, M. M., James, L. E., Allgeier, C., Weitz, J., Kagan, R. J. (2015). Clinical Safety and Efficacy of Probiotic Administration Following Burn Injury. Journal of Burn Care & Research, 36 (1), 92–99. doi: http://doi.org/10.1097/bcr.0000000000000139
  • Marteau, P. R. (2002). Probiotics in clinical conditions. Clinical Reviews in Allergy & Immunology, 22 (3), 255–273. doi: http://doi.org/10.1007/s12016-002-0011-0
  • Shanahan, F. (2012). A Commentary on the Safety of Probiotics. Gastroenterology Clinics of North America, 41 (4), 869–876. doi: http://doi.org/10.1016/j.gtc.2012.08.006
  • Doron, S., Snydman, D. R. (2015). Risk and Safety of Probiotics. Clinical Infectious Diseases, 60 (suppl_2), S129–S134. doi: http://doi.org/10.1093/cid/civ085
  • Gasser, F. (1994). Safety of lactic-acid bacteria and their occurrence in human clinical infections. Bulletin de L'Institut Pasteur, 92, 45–67.
  • Saxelin, M., Chuang, N.-H., Chassy, B., Rautelin, H., Makela, P. H., Salminen, S., Gorbach, S. L. (1996). Lactobacilli and Bacteremia in Southern Finland, 1989-1992. Clinical Infectious Diseases, 22 (3), 564–566. doi: http://doi.org/10.1093/clinids/22.3.564
  • Borriello, S. P., Hammes, W. P., Holzapfel, W., Marteau, P., Schrezenmeir, J., Vaara, M., Valtonen, V. (2003). Safety of Probiotics That Contain Lactobacilli or Bifidobacteria. Clinical Infectious Diseases, 36 (6), 775–780. doi: http://doi.org/10.1086/368080
  • Bernardeau, M., Vernoux, J. P., Henri-Dubernet, S., Guéguena, M. (2008). Safety assessment of dairy microorganisms: the Lactobacillus genus. International Journal of Food Microbiology, 126 (3), 278–285. doi: http://doi.org/10.1016/j.ijfoodmicro.2007.08.015
  • Guidelines for the Evaluation of Probiotics (2002). Food Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food London Ontario. Canada. Available at: https://www.who.int/foodsafety/fs_management/en/probiotic_guidelines.pdf
  • Saarela, M., Mogensen, G., Fondén, R., Mättö, J., Mattila-Sandholm, T. (2000). Probiotic bacteria: safety, functional and technological properties. Journal of Biotechnology, 84 (3), 197–215. doi: http://doi.org/10.1016/s0168-1656(00)00375-8
  • Ishibashi, N., Yamazaki, S. (2001). Probiotics and safety. The American Journal of Clinical Nutrition, 73 (2), 465s–470s. doi: http://doi.org/10.1093/ajcn/73.2.465s
  • Doron, S., Hibberd, P. L., Goldin, B., Thorpe, C., McDermott, L., Snydman, D. R. (2015). Effect of Lactobacillus rhamnosus GG Administration on Vancomycin-Resistant Enterococcus Colonization in Adults with Comorbidities. Antimicrobial Agents and Chemotherapy, 59 (8), 4593–4599. doi: http://doi.org/10.1128/aac.00300-15
  • Holzapfel, W. H., Haberer, P., Geisen, R., Björkroth, J., Schillinger, U. (2001). Taxonomy and important features of probiotic microorganisms in food and nutrition. The American Journal of Clinical Nutrition, 73 (2), 365s–373s. doi: http://doi.org/10.1093/ajcn/73.2.365s
  • Klein, G. (2011). Antibiotic Resistance and Molecular Characterization of Probiotic and ClinicalLactobacillusStrains in Relation to Safety Aspects of Probiotics. Foodborne Pathogens and Disease, 8 (2), 267–281. doi: http://doi.org/10.1089/fpd.2010.0672
  • Stefanov, A. V. (Ed.) (2002). Doklinicheskie issledovaniia lekarstvennykh sredstv. Metodicheskie rekomendatsii. Kyiv: Avitsena, 568.
  • Liaskovskii, T. M., Podgorskii, V. S. (2005). Otsenka probiotikov soglasno rekomendatsii mezhdunarodnykh organizatsii (FAO/WHO). Mikrobiologicheskii zhurnal, 67 (6), 104–112.