Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: an observational retrospective study
Creators
- Jean Regina1
- Matthaios Papadimitriou-Olivgeris1
- Raphaël Burger2
- Paraskevas Filippidis1
- Jonathan Tschopp11
- Florian Desgranges1
- Benjamin Viala1
- Eleftheria Kampouri1
- Laurence Rochat1
- David Haefliger1
- Mehdi Belkoniene2
- Carlos Fidalgo2
- Antonios Kritikos1
- Katia Jaton3
- Laurence Senn4
- Pierre-Alexandre Bart2
- Jean-Luc Pagani5
- Oriol Manuel1
- Loïc Lhopitallier1
- 1. Service of Infectious Diseases, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- 2. Service of Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- 3. Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- 4. Service of Hospital Preventive Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- 5. Service of Intensive Care, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
Description
This is the dataset of the study called "Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: an observational retrospective study".
Abstract:
Background
Coronavirus disease 2019 (COVID-19) is now a global pandemic with Europe and the USA at its epicenter. Little is known about risk factors for progression to severe disease in Europe. This study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital.
Methods
This retrospective observational study included all adult patients hospitalized with a laboratory confirmed SARS-CoV-2 infection from March 1 to March 25, 2020. We extracted data from electronic health records. The primary outcome was the need to mechanical ventilation at day 14. We used multivariate logistic regression to identify risk factors for mechanical ventilation. Follow-up was of at least 14 days.
Results
200 patients were included, of whom 37 (18·5%) needed mechanical ventilation at 14 days. The median time from symptoms onset to mechanical ventilation was 9·5 days (IQR 7.00, 12.75). Multivariable regression showed increased odds of mechanical ventilation in males (3.26, 1.21-9.8; p=0.025), in patients who presented with a qSOFA score ≥2 (6.02, 2.09-18.82; p=0.001), with bilateral infiltrate (5.75, 1.91-21.06; p=0.004) or with a CRP of 40 mg/l or greater (4.73, 1.51-18.58; p=0.013).
Conclusions
This study gives some insight in the epidemiology and clinical course of patients admitted in a European tertiary hospital with SARS-CoV-2 infection. Male sex, high qSOFA score, CRP of 40 mg/l or greater and a bilateral radiological infiltrate could help clinicians identify patients at high risk for mechanical ventilation.
Files
Data.csv
Files
(466.7 kB)
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