Nanoengineering multifunctional hybrid interfaces using adhesive glycogen nanoparticles

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a. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia. E-mail: fcaruso@unimelb.edu.au bSchool of Science, RMIT University, Melbourne, Victoria 3000, Australia. E-mail: francesca.cavalieri@rmit.edu.au
b. Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma ‘‘Tor
Vergata’’, via della ricerca scientifica 1, 00133, Rome, Italy. E-mail: francesca.cavalieri@rmit.edu.au
Electronic Supplementary Information (ESI) available: Synthesis of L-PG, DD-PG and AuNP, details on experimental procedures and materials characterization. See DOI: 10.1039/x0xx00000x
Received 00th January 20xx,
Accepted 00th January 20xx
DOI: 10.1039/x0xx00000x
Nanoengineering multifunctional hybrid interfaces using adhesive glycogen nanoparticles
Pietro Pacchin Tomanina, Jiajing Zhoua, Alessia Amodioa, Rita Ciminoa, Agata Glaba, Francesca Cavalierib,c,*, Frank Carusoa,*
Multifunctional and biodegradable nanostructured hybrid interfaces based on biopolymers are potentially useful in many applications in catalysis, bioanalytical sensing and nanomedicine. Herein, we report the engineering of multifunctional hybrid films by assembling adhesive biological nanoparticles i.e. lipoate-conjugated phytoglycogen (L-PG). These nano building blocks possess adhesive properties, arising from their amphiphilic nature, and reactive functional disulfide groups. The assembly of L-PG on surfaces enabled the rapid and conformal deposition of a thin film on substrates of varying chemical composition and wettability. The L-PG films showed negligible cytotoxicity and moderate stability under different harsh conditions but displayed enzyme-mediated degradability. In addition, metal nanoparticles were embedded into the L-PG layers to build up multilayered hybrid films. Specifically, Au and Ag nanoparticle-loaded L-PG multilayered films with catalytic and surface-enhanced Raman scattering properties were prepared. Finally, we highlight the versatility of the present approach to engineer multifaceted interfaces for catalysis and sensing applications.