Published April 30, 2020
| Version V2_20200429
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Methodological approaches for personalised medicine: protocol for a series of scoping reviews
Creators
- 1. Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
- 2. European Clinical Research Infrastructure Network (ECRIN), Paris, France
- 3. Parc Sanitari San Joan de Déu, San Boi del Llobregat, Barcelona, Spain
- 4. Luxembourg CentrUniversité du Luxembourg, Luxembourg
- 5. European infrastructure for Translational Medicine, (EATRIS), Amsterdam, The Netherlands
- 6. University of Bergen, Bergen, Norway
- 7. Université Paris Descartes, Paris, France
Description
This is the protocol for a series of scoping reviews that will map the general concept of methods for personalised medicine, to set the basis for the discussion on robustness and reproducibility of personalised medicine development programmes. The final goal is the identification of standards and needs in terms of methodology of data generation, management, analysis and interpretation to improve clinical studies in personalised medicine.
For the purpose of this review, four main aspects of the general concept of personalised medicine will be analysed:
- Methods for stratification and validation cohorts
- Methods for machine learning applied to stratification
- Pre-clinical methods for translational development of treatment options and treatments selection
- Methods for clinical trials in personalised medicine
Files
Permit_WP2 scoping review_V2.pdf
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(409.6 kB)
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