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Published April 24, 2020 | Version v0.5.0
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LIGER (Linked Inference of Genomic Experimental Relationships)

Creators

  • 1. University of Michigan
  • 2. The Broad Institute

Description

LIGER is an R package for integrating and analyzing multiple single-cell datasets, developed and maintained by the Macosko Lab and Welch Lab. It relies on integrative non-negative matrix factorization to identify shared and dataset-specific factors.

Check out our Cell paper for a more complete description of the methods and analyses. To access data used in our SN and BNST analyses, visit our study on the Single Cell Portal.

Notes

This work was supported by NIH grants R01 AI149669-01 and R01 HG010883-01 (JDW) and U19 1U19MH114821 (EZM). A patent application on LIGER has been submitted by The Broad Institute, Inc. and The General Hospital Corporation with EZM, JDW and VK as inventors.

Files

MacoskoLab/liger-v0.5.0.zip

Files (46.2 MB)

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Additional details

Related works

Is supplement to
https://github.com/MacoskoLab/liger/tree/v0.5.0 (URL)

References

  • Welch, J. D. et al. Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity. Cell 177, 1873–1887.e17 (2019).