Coenzyme Q0 induces apoptosis, senescence and trans-differentiation of activated hepatic stellate cells
- 1. School of Pharmaceutical Science, Jiangnan University, Wuxi, Jiangsu, China
- 2. National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, Jiangsu, China; Jiangsu Engineering Research Center for Bioactive Products Processing Technology, Jiangnan University, Wuxi 214122, P.R. China
- 3. National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, Jiangsu, China; Jiangsu Engineering Research Center for Bioactive Products Processing Technology, Jiangnan University, Wuxi 214122, P.R. China; The Key Laboratory of Industrial Biotechnology, Ministry of Education; School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China
Description
Figure S1: Pathway functional enrichment of Coenzyme Q0 (7µM) vs control group. Bubble diagram showed KEGG pathway enrichment analysis. X-axis is enrichment ratio [Term Candidate Gene Number/Term Gene Number ], Y-axis is KEGG Pathway, the size of bubbles represents the number of genes annotated to KEGG Pathway, the color represents enrichment Q value, and the darker the color represents Q value, the smaller the value.
Figure S2: Enrichment of DEGs in GO compared with the 7µM coenzyme Q0 treatment group. Gene ontology is divided into three major functional categories: molecular function (molecular function), cellular component (cellular component) and biological process (biological process). Perform functional classification based on the results of differential genetic testing. Under each major category, there are sub-categories of respective levels. Plot the GO annotation classification results of differential genes. The X axis represents the number of genes annotated into the GO cylinder, and the Y axis represents GO functional classification.
Table S1: The expression levels of differentially expressed genes identified in three comparison groups ( CTL, 7μM CoQ0 treatment, 14μM CoQ0 treatment).
Figure S1: Pathway functional enrichment of Coenzyme Q0 (7µM) vs control group. Bubble diagram showed KEGG pathway enrichment analysis. X-axis is enrichment ratio [Term Candidate Gene Number/Term Gene Number ], Y-axis is KEGG Pathway, the size of bubbles represents the number of genes annotated to KEGG Pathway, the color represents enrichment Q value, and the darker the color represents Q value, the smaller the value.
Figure S2: Enrichment of DEGs in GO compared with the 7µM coenzyme Q0 treatment group. Gene ontology is divided into three major functional categories: molecular function (molecular function), cellular component (cellular component) and biological process (biological process). Perform functional classification based on the results of differential genetic testing. Under each major category, there are sub-categories of respective levels. Plot the GO annotation classification results of differential genes. The X axis represents the number of genes annotated into the GO cylinder, and the Y axis represents GO functional classification.
Table S1: The expression levels of differentially expressed genes identified in three comparison groups ( CTL, 7μM CoQ0 treatment, 14μM CoQ0 treatment).
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