Establishment and Characterization of Humanized Mouse NPC-PDX Model for Testing Immunotherapy

Supplementary Materials: Figure S1: Gating strategy for NK cell, macrophage and T cell subsets, Figure S2: Modulation of immune cell subsets in blood in the presence of NPC in humanized mice, Figure S3: Modulation of immune cell subsets in spleen in the presence of NPC in humanized mice, Figure S4: Modulation of tumor-infiltrating immune cells in another NPC-PDX, Figure S5: Evaluation of the anti-tumor efficacy of nivolumab and ipilimumab in humanized mice, Figure S6: Modulation of immune cell profile in tumor after combination immunotherapy using another NPC-PDX, Table S1: FACS antibodies used in the present study.