Immunogenomics of colorectal cancer response to immune checkpoint blockade: TCRseq

Published April 8, 2020 | Version v1

Dataset Restricted

1. Cancer Systems Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK; School of Cancer and Pharmaceutical Sciences, King's College London, London SE11UL, UK
2. Biomedical Research Centre, Guy's and St. Thomas' NHS Trust, London SE1 9RT, UK
3. Advanced Sequencing Facility, the Francis Crick Institute, London NW1 1AT, UK
4. Cancer Evolution and Genome Instability Laboratory Francis Crick Institute, London NW1 1AT, UK; CRUK Lung Cancer Centre of Excellence, UCL Cancer Institute, London WC1E 6DD, UK
5. School of Immunology and Microbial Sciences, King's College London, London SE1 9RT, UK
6. FASTBASE Solutions S.L, Astondo bidea, Kabi 612 Scientific and Technology Park of Bizkaia 48160 Derio, Spain
7. FASTBASE Solutions, Scientific and Technology Park 48160 Derio, Spain ; Centre for Therapeutic Innovation, University of Bath, Bath BA2 7AY, UK
8. Protein Phosphorylation Laboratory, Francis Crick Institute, 1 Midland Rd, London NW1 1AT, UK; School of Cancer and Pharmaceutical Sciences, King's College London, London SE11UL, UK
9. Department of Histopathology, University College London Cancer Institute, London WC1E 6JJ, UK
10. University College London NHS Foundation Trust, London NW1 2PG, UK

Immunogenomics of colorectal cancer response to immune checkpoint blockade

TCR-seq data supporting the paper: "Immunogenomics of colorectal cancer response to immune checkpoint blockade"

Both files were downloaded from the Adaptive Biotechnologies immunoSeq Analyzer portal on 17/12/2019.

RearrangementDetails_12-17-2019_9-06-47_AM.tsv: contains the detailed productive rearrangement data for all 28 regions sequenced. For each region, data includes the nucleotide sequence, the amino acid sequence, the V, D, and J gene and allele identifications and the frequency of all the productive rearrangements in that region.
SampleOverview_12-17-2019_9-03-56_AM.tsv: contains the region-level data that includes absolute number of rearrangements and productive rearrangements and productive clonality for all 28 regions sequenced.

The record is publicly accessible, but files are restricted to users with access.

If you would like to request access to these files, please fill out the form below.

The restriction is only for tracking and logging purposes, access will be granted upon request. Please write your name and affiliations to the following email addresses:
francesca.ciccarelli@kcl.ac.uk
michele.bortolomeazzi@kcl.ac.uk

You are currently not logged in. Do you have an account? Log in here

Description