Published March 27, 2020 | Version v1
Journal article Open

Copy Number Variations in Adult Patients with Chronic Immune Thrombocytopenia

Creators

  • 1. Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biology
  • 2. Istanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Genetics
  • 3. Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Division of Haematology, Department of Internal Medicine
  • 4. Acibadem Mehmet Ali Aydinlar University, School of Medicine, Department of Medical Genetics

Description

In this report we identified CNV regions unique to adult ITP patients. Despite several studies the genetic background of ITP is still unclear. There are studies on pediatric cases, describing several genes associated with the disease, but the data is still limited. Here, we aimed to identify regions that may play a role in the pathogenesis of adult ITP by SNP array technology. Our findings support the idea that ITP is not only clinically but also genetically heterogeneous and genetic modifiers play an important role in the development of the disease. We believe that this data will provide important bases for the future studies to enlighten ITP pathogenesis.

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