Service Incident: New DOI registrations are working again. Re-registration of failed DOI registrations (~500) are still affected by the service incident at DataCite (our DOI registration agency).

There is a newer version of the record available.

Published March 23, 2020 | Version 1.0
Report Open

Statistical review of Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.

  • 1. HRB Clinical Research Facility - Cork. HRB Trial Methodology Research Network. University College Cork School of Public Health
  • 2. Cancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, UK
  • 3. MRC Clinical Trials Unit at University College London

Description

The following review has been prepared by members of the MRC-NIHR Trials Methodology Research Partnership. The reviewers are all qualified statisticians with experience in clinical trials. Our objective is to provide a rapid review of publications, preprints and protocols from clinical trials of COVID-19 treatments, independent of journal specific review processes. We aim to provide timely, constructive, focused, clear advice aimed at improving both the  research outputs under review, as well as future studies. Given our collective expertise (clinical trial statistics) our reviews focus on  the designs of the trials and other statistical content (methods, presentation and accuracy of results, inferences).

Here we review Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical  trial, by Gautret et al . When we started our review, the paper was being circulated via Google Drive. Shortly after, it was accepted  for publication in the International Journal of Antimicrobial Agents, and posted on MedRxiv.org. However, these versions of the  study report were the same as the one we reviewed, indicating no or limited external peer review for the final published version.

Files

Review 20_03_20_001.pdf

Files (659.5 kB)

Name Size Download all
md5:c2b5fb4d0a06df5a07d0db7121b709c8
659.5 kB Preview Download