Breast Dynamic Contrast Enhanced MRI: Fibrocystic Changes Presenting as a Non-mass Enhancement Mimicking Malignancy
Creators
- 1. Clinic for Radiation Oncology and Radiology, Institute of Oncology and Radiology of Serbia, Belgrade, Serbia
- 2. Department for Pathology, Institute of Oncology and Radiology of Serbia, Belgrade, Serbia
- 3. Primary Health Center Zvezdara, Belgrade, Serbia
- 4. Institute for Biological Research 'Sinisa Stankovic', Belgrade, Serbia
Description
Background: We aimed to analyse the morphokinetic features of breast fibrocystic changes (nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia) presenting as a non-mass enhancement (NME)in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) examination. Patients and methods: Forty-six patients with histologically proven fibrocystic changes (FCCs) were retrospectively reviewed, according to Breast Imaging Reporting and Data System (BI-RADS) lexicon. Prior to DCE-MRI examination, a unilateral breast lesion suspicious of malignancy was detected clinically, on mammography or breast ultrasonography. Results: The predominant features of FCCs presenting as NME in DCE-MRI examination were: unilateral regional or diffuse distribution (in 35 patients or 76.1%), heterogeneous or clumped internal pattern of enhancement (in 36 patients or 78.3%), plateau time-intensity curve (in 25 patients or 54.3%), moderate or fast wash-in (in 31 patients or 67.4%).Nonproliferative lesions were found in 11 patients (24%), proliferative lesions without atypia in 29 patients (63%) and lesions with atypia in six patients (13%), without statistically significant difference of morphokinetic features, except of the association of clustered microcysts with proliferative dysplasia without atypia. Conclusions: FCCs presenting as NME in DCE-MRI examination have several morphokinetic features suspicious of malignancy, therefore requiring biopsy (BI-RADS 4). Nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia predominantly share the same predefined DCE-MRI morphokinetic features.
Notes
Files
[Radiology and Oncology] Breast dynamic contrast enhanced MRI fibrocystic changes presenting as a non-mass enhancement mimicking malignancy(4).pdf
Files
(614.9 kB)
Name | Size | Download all |
---|---|---|
md5:2ffcd70c5c43b0b682a86492a1acf588
|
614.9 kB | Preview Download |
Additional details
Identifiers
- PMID
- 28740447
Related works
- Is part of
- 1318-2099 (ISSN)