Dataset related to article "Re-irradiation for recurrent glioma: outcome evaluation, toxicity and prognostic factors assessment. A multicenter study of the Radiation Oncology Italian Association (AIRO)"
Creators
- Navarria P1
- Minniti G2
- Clerici E1
-
Tomatis S1
- Pinzi V3
- Ciammella P4
- Galaverni M4
- Amelio D5
- Scartoni D5
- Scoccianti S6
- Krengli M7
- Masini L7
- Draghini L8
- Maranzano E8
- Borzillo V9
- Muto P9
- Ferrarese F10
- Fariselli L11
- Livi L12
- Pasqualetti F13
- Fiorentino A14
- Alongi F14
- di Monale MB15
- Magrini S15
-
Scorsetti M16
- 1. Humanitas Clinical and Research Center – IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy
- 2. Advanced Radiotherapy Center, UPMC San Pietro FBF, Roma, Italy.
- 3. Radiotherapy Unit, Istituto Neurologico Fondazione "Carlo Besta", Milan, Italy.
- 4. Radiation Therapy Unit, Department of Oncology and Advanced Technology, Azienda Ospedaliera Arcispedale S Maria Nuova, Reggio Emilia, Italy.
- 5. Proton Therapy Center, Azienda Provinciale per I Servizi Sanitari (APSS), Trento, Italy.
- 6. Radiation Oncology Unit, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.
- 7. Radiotherapy Unit, Department of Translation Medicine, University of Piemonte Orientale, Novara, Italy.
- 8. Radiotherapy Oncology Centre, "S. Maria" Hospital, Terni, Italy.
- 9. UOC Radiation Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori -Fondazione "Giovanni Pascale", Naples, Italy.
- 10. Radiation Therapy, Ospedale Ca' Foncello di Treviso, Treviso, Italy.
- 11. Radiotherapy Unit, Istituto Neurologico Fondazione "Carlo Besta", Milan, Italy
- 12. Radiation Oncology Unit, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
- 13. Radiation Oncology, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
- 14. Radiation Oncology, Sacro Cuore Don Calabria Hospital, Negrar-Verona, Italy.
- 15. Department of Radiation Oncology, University and Spedali Civili Hospital, Brescia, Italy.
- 16. Humanitas Clinical and Research Center – IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy AND Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele – Milan, Italy
Description
Abstract
INTRODUCTION:
The prognosis of glioma is dismal, and almost all patients relapsed. At recurrence time, several treatment options are considered, but to date there is no a standard of care. The Neurooncology Study Group of the Italian Association of Radiation Oncology (AIRO) collected clinical data regarding a large series of recurrent glioma patients who underwent re-irradiation (re-RT) in Italy.
METHODS:
Data regarding 300 recurrent glioma patients treated from May 2002 to November 2017, were analyzed. All patients underwent re-RT. Surgical resection, followed by re-RT with concomitant and adjuvant chemotherapy was performed. Clinical outcome was evaluated by neurological examination and brain MRI performed, 1 month after radiation therapy and then every 3 months.
RESULTS:
Re-irradiation was performed at a median interval time (IT) of 16 months from the first RT. Surgical resection before re-RT was performed in 19% of patients, concomitant temozolomide (TMZ) in 16.3%, and maintenance chemotherapy in 29%. Total doses ranged from 9 Gy to 52.5 Gy, with a median biological effective dose of 43 Gy. The median, 1, 2 year OS were 9.7 months, 41% and 17.7%. Low grade glioma histology (p ≪ 0.01), IT > 12 months (p = 0.001), KPS > 70 (p = 0.004), younger age (p = 0.001), high total doses delivered (p = 0.04), and combined treatment performed (p = 0.0008) were recorded as conditioning survival.
CONCLUSION:
our data underline re-RT as a safe and feasible treatment with limited rate of toxicity, and a combined ones as a better option for selected patients. The identification of a BED threshold able to obtain a greater benefit on OS, can help in designing future prospective studies.
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Additional details
Related works
- Is supplement to
- 0515706 (PMID)
- 10.1007/s11060-018-03059-x (DOI)