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Finalization of case studies and analysis of remaining weaknesses (Deliverable 1.5)

Jennings, Paul; Doganis, Philip; Karatzas, Pantelis; Tsiros, Periklis; Sarimveis, Haralambos; Farcal, Lucian; Exner, Thomas; Mohoric, Tomaz; Raza, Atif; Brochot, Celine; Tebby, Cleo; Martens, Marvin; Willighagen, Egon; Jennen, Danyel

The OpenRiskNet case studies (originally outlined in Deliverable 1.3) were developed to demonstrate the modularised application of interoperable and interlinked workflows. These workflows were designed to address specific aspects required to inform on the potential of a compound to be toxic to humans and to eventually perform a risk assessment analysis. While each case study targets a specific area including data collection, kinetics modelling, omics data and Quantitative Structure Activity Relationships (QSAR), together they address a more complete risk assessment framework. Additionally, the modules here are fine-tuned for the utilisation and application of new approach methodologies (NAMs) in order to accelerate the replacement of animals in risk assessment scenarios. These case studies guided the selection of data sources and tools for integration and acted as examples to demonstrate the OpenRiskNet achievements to improve the level of the corresponding APIs with respect to harmonisation of the API endpoints, service description and semantic annotation.

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