Published March 1, 2020
| Version v1
Journal article
Open
Targeting ncRNAs by plant secondary metabolites: The ncRNAs game in the balance towards malignancy inhibition
- 1. MEDFUTURE - Research Center for Advanced Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 23 Marinescu Street, 400337, Romania
- 2. Department of Medical Biology, Faculty of Medicine, Medical University-Plovdiv, 15-А Vassil Aprilov Blvd., Plovdiv 4000, Bulgaria ; Technological Center for Emergency Medicine, 15-АVassil Aprilov Blvd., Plovdiv 4000, Bulgaria ; Center of Plant Systems Biology and Biotechnology Ruski Blvd. 139, Plovdiv 4000, Bulgaria
- 3. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
- 4. The Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Postępu 36A, Jastrzębiec, 05-552 Magdalenka, Poland ; Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria. ; Center for Physiology and Pharmacology, Institute for Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
- 5. MEDFUTURE - Research Center for Advanced Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 23 Marinescu Street, 400337, Romania ; Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 23 Marinescu Street, 400337, Cluj-Napoca, Romania ; Department of Functional Genomics and Experimental Pathology, The Oncology Institute "Prof. Dr. Ion Chiricuta", Republicii 34 Street, 400015, Cluj-Napoca, Romania
Description
Abstract
The current trend of combining state of the art technologies with quondam treatments in order to overcome existing gaps in clinics determined an increased interest into polyphenols, common dietary phytochemicals, for the prevention and treatment of chronic diseases, especially cancer. The reemergence of polyphenols in the cancer field is sustained by transcriptomics technologies able to identify coding and non-coding genes and their related signaling pathways modulated by natural compounds. Identification of the structural correspondence between interacting molecules will allow the development of more targeted and informed therapeutic strategies for cancer management.
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