AN ASSESSMENT OF FASTING LIPID PROFILE IN PATIENTS OF CHRONIC KIDNEY DISEASE PRESENTING AT TERTIARY CARE HOSPITAL

Objective: To assess the fasting lipid profile in patients of chronic kidney disease presenting at tertiary care hospital. 

Material and methods: This case control study was conducted at Department of Department of Pathology, Sahiwal Medical College, Sahiwal from February 2019 to August 2019 over the period of 6 months.  Total 50 health control, 50 CKD patients with out hemodialysis and 50 CKD patients on hemodialysis were selected.  Age range in this study was 18-80 years.  Mean lipid parameters were studied in all groups. 

Results: Mean age of the patients in group A (controls), group B (CKD patients with out hemodialysis) and group C (CKD patients on hemodialysis) was 39.92±16.59 years, 42.02±14.30 years  and 48.08±13.15 years.  In group A male/female were 22 (44%) / 28 (56%), in group B was 36 (72%) / 14 (28%) and in group C was 28 (56%) /22 (44%).  Mean BMI in group A was 22.43±2.14 followed by group B 22.99±1.90 and in group C was 22.86±2.11.  Total cholesterol, HDL, LDL, TG and VLDL in controls vs CKD patients was 130.59±16.12 vs 195.21±24.64, 54.21±3.94 vs 38.35±4.01, 94.96±18.83 vs 153.07±23.84, 94.02±19.92 vs 205.75±53.40 and 13.96±3.78 vs 29.14±16.33 respectively.  Difference of mean lipid parameters between controls and CKD patients was statistically significant.

Conclusions: Results of present study showed there is a  significant difference of mean lipid parameters between controls and CKD patients.  Difference of mean HDL, mean TG and mean VLDL between CKD patients without hemodialysis and CKD patients on hemodialysis was statistically significant.

Keywords: Chronic kidney disease, Cardiovascular disease, Hemodialysis, Lipid profile