Summary-level data from GWAS meta-analysis of heart failure and multi-omic analyses of differentiating cardiomyocytes

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Summary-level data as presented in:

"Genome-wide association and multi-omic analyses reveal new mechanisms for Heart Failure" Arvanitis et al. 2019; Preprint at: https://www.medrxiv.org/content/10.1101/19006510v2

**If you use this data please cite the above paper

Marios Arvanitis

marvani1@jhmi.edu

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Data files:

1. META_clean.tsv.gz

Summary statistics of the Discovery GWAS meta-analysis. Max N=448,549.

2. hESC-CM_ACTN2_locus_seq.bed

Bed file containing the RPKM values for ATAC-seq, H3K27ac-seq, H3K4me1-seq and RNA-seq on Days 0, 2, 5, 7, 15, 80 of cardiomyocyte differentiation from hESCs for the chromosome 1 GWAS locus near the ACTN2 gene.

3. raw_sequence_data.zip

ATAC-seq and H3K4me1-seq raw sequences for the chromosome 1 GWAS locus near the ACTN2 gene in BAM format.

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Data file format:

1. META_clean.tsv.gz

chrpos: SNP name in the format chromosome:position@AlleleA@AlleleB

rsid: SNP name in dbSNP identifiers

Allele1: Effect allele

Allele2: Non-effect allele

Effect: log(Odds Ratio (OR)) of Heart Failure

StdErr: Standard Error of log(OR)

P-value: Nominal p-value of the effect

chr: SNP chromosome in hg19

pos: SNP position in hg19

Weight: Total N associated with each SNP in the meta-analysis

2. hESC-CM_ACTN2_locus_seq.bed

Column 1: Chromosome in hg38

Column 2: Start position in hg38

Column 3: End position in hg38

Column 4: RPKM value

Column 5: Sequencing type and day of differentiation

3. raw_sequence_data.zip

Compressed folder that contains individual BAM files for ATAC-seq and H3K4me1-seq for different stages of cardiomyocyte differentiation.

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