Pathogenesis of Non-Specific Neurological Signs and Symptoms in Aircrew on Civil Aircraft

This paper addresses the basic neurobiology which leads to the brain being a ‘target organ’ for chronic low dose organo-phosphate toxicity. This includes the irreplaceability of nerve cells, the logistic problems neurons have in serving axons (that in some neurons can be over one meter long), the dependence of neurons on neurotrophins, and the vulnerability of neurons to damage through impairment of axonal transport.