Preparation and Biological Screening of Novel Heterocyclic Compounds

The Pyrimidone derivatives say, N arylidine 6 methyl 2 oxo 4 phenyl 1,2,3, 4 tetrahydropyrimidonecarbohydrazides 2a e were synthesized by condensation of Benzaldehyde derivatives with 6 Methyl 2 oxo 4 phenyl 1,2,3,4 tetrahydro pyrimidone carbohydrazides 1 in good yield. The so called hydrazone were cyclocondensed with succinic anhydride to afford 1 6 methyl 2 oxo 4 phenyl 1,2,3, 4 tetrahydropyrimidone 5 carboxamido 5 oxo 2 aryl pyrrolidine 3 carboxylic acid 3a e . These 3a e on Mannich reaction with formaldehyde and morpholine offered 2 aryl 1 6 methyl 2 oxo 4 phenyl 1, 2, 3, 4 tetrahydropyrimidine 5 carboxamido 4 morpholinomethyl 5 oxopyrrolidine 3 carboxylic acid 4a e . Further 4a e on condensation with 1, 2 benzenediamine yield N 3 1H benzo d imidazol 2 yl 2 aryl 4 morpholinomethyl 5 oxopyrro lidin 1 yl 6 methyl 2 oxo 4 phenyl 1, 2, 3, 4 tetrahydropyrimidine 5 carboxamide 5a e . Their structures were confirmed by elemental contents and spectral features. The antimicrobial activities of all three series have also been evaluated. The whole synthetic route is shown below. Pranay Shah | R. I. Patel | P. J. Vyas "Preparation and Biological Screening of Novel Heterocyclic Compounds" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-3 , April 2019, URL: https://www.ijtsrd.com/papers/ijtsrd22815.pdf