Preprint Open Access
del Rosal, Blanca; Ruiz, Diego; Chaves-Coira, Irene; H. Juárez, Beatriz; Monge, Luis; Hong, Guosong; Fernández, Nuria; Jaque, Daniel
Despite attracting increased attention from clinicians, brain temperature distribution, fluctuations and changes in response to external stimuli are still largely unknown and refractory to conventional temperature-probing approaches. Fluorescence nanothermometry in the second near-infrared window (NIR-II window, 1,000-1,700 nm), as shown here, can provide contactless brain thermal sensing through the scalp and skull in real-time with a sub-degree resolution. As a proof of concept, Ag2S nanothermometers have been used to monitor brain thermoregulation in a cooling/heating process and temperature changes associated with a barbiturate coma.