Is the gut Microbiome an Important Trigger of Asthma Development?

Asthma is a complicated disease with multiple phenotypes. Th2 cytokines is main orchestrate of asthma pathophysiology. Genetic and environmental factors, psychological and neurological factors, public health problems, allergic reactions, inflammation, respiratory infections, smocking, stress, obesity, exercise, drugs, diet, gastro-esophagus reflux and etc. have notable effects in immune system modulation (which would be resulted dysregulation of immune response) and lead to asthma in airway [1, 2].