Journal article Open Access

FORMULATION AND EVALUATION OF FAST DISSOLVING TELMISARTAN TABLET BY INCLUSION COMPLEXATION KNEADING METHOD

Sandeep.Ashokrao Wathore*

Telmisartan is a potent, long‐lasting, nonpeptide antagonist of the angiotensin II type‐1 (AT1) receptor that is indicated for the treatment of essential hypertension. It selectively and insurmountably inhibits stimulation of the AT1 receptor by angiotensin II without affecting other receptor systems involved in cardiovascular regulation. Poor water solubility is the main constant for its oral bioavailability. The rationale of this study to enhance solubility and dissolution of the drug by preparing its complex with β cyclodextrin. In the present study attempt has been made to prepare, formulate and characterize inclusion complex of Telmisartan with β cyclodextrin. The inclusion complex prepared by kneading method. The inclusion complex containing Telmisartan:β cyclodextrin (1:5) was further formulated into fast dissolving tablet by direct compression technique using superdisintegrant like sodium starch glycolate. The prepared complex were characterize using FT-IR, DSC and finally fast dissolving tablet were evaluated for various pharmaceutical characteristics viz. Hardness, % Friability, Weight variation, Wetting time, Drug content and in-vitro dissolution profiles.

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