Deliverable Report D5.4 User application for importing NanoSafety Cluster data

The aim of this work is to analyze and choose technical options to implement application and user interfaces for the import of available data from various EU Nanosafety Cluster (EU NSC) projects. Applications are subjected to integrated testing (Task 5.2) and, depending on licenses, data are released for user testing and evaluation (Task 1.4). eNanoMapper has been in contact with various NanoSafety Cluster projects for importing data. Most of this data is expected to be provided as spreadsheets for which a general framework has been developed. We engaged with the following EU Nanosafety Cluster projects: 1. With NANoREG (WP6) we are working on exporting data from their literature capturing database into eNanoMapper and back again, and annotating fields and content with the eNanoMapper ontology along the way. NANoREG also provided confidential Excel templates used to gather data within NANoREG WP2, WP4 and WP5. 2. ModNanoTox was provided as MS Excel spreadsheet files, containing 86 assays with more than 100 different endpoints affecting 45 species. We developed a dedicated command line application, built on top of the configurable spreadsheet data parser, which enables parsing the entire ModNanoTox data and importing into the database. The annotation of fields and content with the eNanoMapper ontology is ongoing. 3. COST Action MODENA agreed to share data with eNanoMapper and provided the Excel files to eNanoMapper. The data was collected for training purposes. This data was first reviewed by MODENA and provided to eNanoMapper as an Excel spreadsheet, containing information on the nanomaterials (NM) identification, characterization, assay performed, test conditions and a few toxicity parameters (ECs). Additionally, MODENA provided Excel templates used within the project to gather literature data (one Excel file per material). These individual templates are then summarized into the spreadsheet for training purposes described above. The MODENA templates are similar (but not exactly the same) to MARINA templates. 4. MARINA project has published an exhaustive paper on the in vitro assessment using representative JRC nanomaterials. Data to be imported refers to the in vitro toxicity of six NMs and was evaluated in 12 cellular models representing 6 different target organs/systems (immune system, respiratory system, gastrointestinal system, reproductive organs, kidney and embryonic tissues). The toxicity assessment was conducted using 10 different assays for cytotoxicity, embryotoxicity, epithelial integrity, cytokine secretion and oxidative stress. In addition, MARINA participant provided confidential Excel templates used to gather the data within the projects, covering variety of physicochemical characterisation experiments and bioassays. 5. NANoPUZZLES project provided confidential data templates, designed to resemble ISA-TAB-Nano structure. NANoPUZZLES plans to release the data with CC-BY license after the end of the project. 6. Exhaustive data on physico-chemical properties of representative nanomaterials used in various EU Nanosafety Cluster projects (e.g. ENPRA, MARINA, and NANoREG) are publicly available via the EC-JRC reports, (https://ec.europa.eu/jrc/en/publications).