Histopathological study on acrylamide induced testicular changes in adult male rats

Acrylamide (ACR) is a common chemical which is used in both industrial and laboratory processes. It is formed in heated starchy foods especially potato products. The present experiment was conducted to investigate the testicular toxicity of acrylamide in adult male rats. Twenty mature male wistar rats were used in this study. Rats were classified randomly into two groups; the first group G1 was received daily saline solution and kept as control. The second group G2 acrylamide was administration daily to animals at dose of 25 mg/kg for 6 consecutive weeks. The results indicated decreased significantly (P< 0.05) in relative weights of testes and body weights of rats treated with acrylamide. Histopathological lesions were also present in the testes of treated rats as vacuolar degeneration and disorder of germ cells, deformed spermatids and seminiferous tubules atrophy, necrotic sertoli cells and lack of spermatozoa in tubular lumen of epididymidis were observed in treated group animals. This may suggest partial depletion of germ cells and different physiology roles for germ cells subunits in spermatogenesis. These changes might affect to reproductive and sexual behavior.