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Published February 28, 2018 | Version v1
Journal article Open

Actual approaches to development of new germicides in the conditions of extension of antibiotic resistance

Creators

  • 1. Danylo Halytsky Lviv National Medical University
  • 2. F. D. Ovcharenko Institute of Biocolloidal Chemistry National Academy of Sciences of Ukraine
  • 3. State Institution "Institute of Traumatology and Orthopaedics of National Academy of Medical Sciences of Ukraine"

Description

Aim. The grounding of expediency of studying the nature of interaction between metal nanoparticles and plasmid DNA of bacteria at the stage of pharmaceutical development of antimicrobial preparations based on metal nanoparticles as separate antimicrobial agents, as well as compositions of metal nanoparticles with known antimicrobial substances.

Methods. Methods of information retrieval and analysis of literature data have been used.

Results. Plasmid transmission of drug resistance is the most important mechanism of resistance in the bacterial population. A promising approach to solve the problem of overcoming the resistance of microorganisms is the use as an active pharmaceutical ingredient of antimicrobial agents caused the destruction of R-plasmids or ensured their irreversible elimination. The study of the interaction of substances with plasmid DNA bacteria and the study of their effect on the transfer of resistance genes in bacterial populations should be used at the first stage of the creation of antimicrobial preparations, when a potential active pharmaceutical ingredient is select.

Conclusion. Creation and introduction into the production of medicines based on silver and gold nanoparticles is a promising direction, because nanoparticles of these metals, along with antimicrobial action, will provide irreversible elimination of plasmid from bacterial cells and can become a solution of the problem with antibiotic resistance

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