Published March 2, 2019 | Version v1
Journal article Open

Syndecan-1 in Liver Diseases

Creators

  • 1. Semmelweis University

Description

Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on the surfaces of hepatocytes and cholangiocytes. Due to liver diseases the amount of syndecan-1 increases in the liver. Despite the emerging data of the biological function of syndecan-1, the clinical usefulness of this proteoglycan is still unknown. In our study we correlated syndecan-1 expression to clinico-pathological data. We found that syndecan-1 proved to be a good marker for hepatitis C virus based hepatocellular carcinoma and increased with liver dysfunction.

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Additional details

Funding

European Commission
GLYCANC – Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer 645756