ANALYSIS OF TUBERCULOSIS METAGENOME TOWARDS PATHOGENICITY AND SCREEN OF INTERLOGS IN HUMAN

ABSTRACT

The infection by Mycobacterium tuberculosis (Mtb) depends greatly on how the host responds to the bacteria and its community and how the bacterial community manipulates the host. Thus, to understand this process, it is important to study the bacterial community first and identify the proteins that mediate pathogenicity. Metagenomic analysis is an approach that facilitates us to study these microbial communities. Once we understand these communities, there is a need for elucidating protein interactions between human and Mtb considering the existing microbiota present in the host. This may enable us to characterize specific molecular mechanisms allowing the bacteria to persist and survive under different environmental conditions. These interactions also will shed light on the interplay between Mtb and its human host. This might contribute to the process of repurposing existing drugs with new biological mechanisms of action.  In this work, we identified 11 interlogs present in human host. After screening we have reported about 78 diseases, which have either direct or indirect effect on different types of tuberculosis. We believe studying these human interlogs targets and screening potential existing drugs for it, might repurpose some existing medicine towards the cure of tuberculosis.

KEYWORDS: Tuberculosis, Metagenome, Network, Interlogs, Human diseases.