ANALYSIS OF LIPID PEROXIDATION STATUS IN CERVICAL CANCER FEMALE PATIENTS AFTER RECEIVING CHEMOTHERAPY

Introduction: Cervical cancer is the second most common cancer in women, and the seventh overall. Risk factors for cervical cancer include: early age at first sexual intercourse, number of sexual partners, malnutrition, smoking and longtime use of oral contraceptives.

Objectives of the study: This study is aim to analyze lipid peroxidation status in cervical cancer female patients after receiving chemotherapy.

Methodology of the study: This cross-sectional study was conducted in Rawalpindi Medical College, Rawalpindi during June 2018 to January 2019. The data was collected from 50 cervical cancer patients. The data was collected through non probability sampling technique. 5.0 ml blood sample was taken from vein. Blood was further processed for the estimation of lipid peroxidation. Commercially available enzymatic kits of Randox were used. Blood was centrifuged at 4000 rpm for 10 minutes and serum was separated.

Results: The data was collected from 50 patients. The statistical analysis shows that levels of MDA become increasing in prostate cancer patients who received adjuvant radiotherapy or simple radiotherapy. The level of MDA before radiotherapy is 3.48±0.65and it become increases in post radiotherapy. As the value of MDA post radiotherapy is 5.66±0.95. But in case of adjuvant radiotherapy it becomes 3.27±0.16 (pre-treatment) and 6.79±0.40 (post-treatment). The levels of MDA become increased because cell membrane is damaged due to therapies.

Conclusion: It is concluded that MDA is one of the important marker of body for protecting the body against the diverse effects of radiotherapy.