A COMPARATIVE RESEARCH TO ASSESS THE EFFECTIVENESS OF LETROZOLE AND CLOMIPHENE CITRATE AMONG INFERTILE ANOVULATORY WOMEN

Objective: The purpose of the research was to compare clomiphene citrate versus letrozole for acquiring auspicious gravidity in anovulatory infertile females.    

Material and Methods: The mode of the research was comparative which was carried out at Jinnah Hospital, Lahore from April 2017 to January 2018.  Total numbers of anovulatory infertility patients in our research are two-hundred and twenty-four having age eighteen to forty years. Entire those patients having a former record of operation, hyperprolactinemia and hypothyroidism were not included in the research. Researcher divides the enrolled patients for research into two categories, category “A” (clomiphene citrate) and category “B” (letrozole) by applying the lottery procedure. A resultants variable such as affectivity was recorded.

Results: The average age of the females in clomiphene citrate group was (26.72 ± 6.02) years and in letrozole group was (26.87 ± 6.33) years. One hundred and forty-eight (66.07%) were between eighteen to thirty years of age. The average interval of infertility was (3.47 ± 2.21) years. The average interval of infertility in clomiphene citrate group was (3.23 ± 2.19) years and in letrozole group was (3.68 ± 2.34) years. The effectuality of clomiphene group (Group “A”) was nineteen (16.96 %) whereas in letrozole group (Group “B”) was thirty-seven (33.04%) with P value =0.005.

Conclusion: The research determined that letrozole is ameliorated and more productive in term of accomplishing gestation in the treatment of anovulatory infertility.

Keyword: Hypothalamic-Pituitary-Ovarian (HPO), Anovulatory, Selective Estrogen-Receptor Modulator (SERM), Non-Polycystic Ovarian Syndrome (PCOS).