SOLID LIPID NANOPARTICLE: A NOVEL APPROACH IN DRUG DELIVERY SYSTEM

ABSTRACT

The solid lipid nanoparticles possess a lipid core matrix in a nanometer range, stabilized by a surfactant layer. These are based on biocompatible lipids and provide sustained effect on the formulation either by diffusion or dissolution. SLN have several advantages over other colloidal carriers, such as the possibility of controlling drug release, long term stability, drug targeting, and good drug loading of drugs may it be lipophilic or hydrophilic, free from biotoxicity due to the use of physiological lipids. The use of solid lipid instead of liquid lipid was much better idea to achieve controlled drug release, as the mobility of the drug in the solid is considerably lower as compared with liquid oils. Due to their biodegradable and biocompatible properties the solid lipid nanoparticles are used to deliver lipophilic drugs, macromolecules, proteins, peptides, genes, antigens, food molecules, hydrophilic drugs and diagnostic molecules.

KEYWORDS: SLNs, Nanotechnology, Colloidal carriers.