Determinants of occurrence and survival after sudden cardiac arrest–A European perspective: The ESCAPE-NET project
Creators
- 1. Université Paris Descartes, INSERM UMRS-970, Paris Cardiovascular Research Centre, Paris, France
- 2. Department of Cardiology, Heart Center, Academic Medical Center, Amsterdam, The Netherlands
- 3. European Resuscitation Council, Brussels, Belgium; Department of Anesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany
- 4. European Heart Rhythm Association, representing the European Society of Cardiology, Sophia Antipolis, France
- 5. VU University Medical Center, Amsterdam, The Netherlands
- 6. Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark and Danish Heart Foundation
- 7. Department of Human Genetics, Helmholtz Center, Munich, Germany
- 8. IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy; Italian Resuscitation Council, Bologna, Italy
- 9. IRCCS Istituto Auxologico Italiano, Reference Network for Rare and Low Prevalence Complexe Diseases of the Heart (ERN GUARD-HEART), Italy
- 10. Center for Resuscitation Science, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden
- 11. The Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark and Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Denmark and Reference Network for Rare and Low Prevalence Complexe Diseases of the Heart (ERN GUARD-HEART)
- 12. Emergency Medical Services of the Hradec Kralove Region, Czech Republic
Description
Aims: The ESCAPE-NET project (“European Sudden Cardiac Arrest network– towards Prevention, Education
and New Effective Treatments”) aims to study: (1) risk factors and mechanisms for the occurrence
of sudden cardiac arrest (SCA) in the population, and (2) risk factors and treatment strategies for survival
after SCA on a European scale.
Methods: This is an Horizon2020 funded program of the European Union, performed by a European publicprivate
consortium of 16 partners across 10 EU countries. There are 11 deep-phenotyped SCA cohorts for
the study of risk factors and treatment strategies for survival after SCA, and 5 deep-phenotyped observational
prospective population cohorts for the study of risk factors for occurrence of SCA. Personalized
risk scores for predicting SCA onset and for predicting survival after SCA will be derived and validated.
Results: The 11 clinical studies with SCA cases comprise 85,790 SCA cases; the 5 observational prospective
population cohorts include 53,060 subjects. A total of 15,000 SCA samples will be genotyped for common
and rare variants at the Helmholtz Zentrum München (Germany) using the Illumina Global Screening
Array which contains > 770,000 SNPs, and after imputation, a database of an estimated > 9 million variants
will be available for genome wide association studies. Standardization of risk factors definition
and outcomes is ongoing. An Executive Committee has been created along with a Collaboration Policy
document.
Conclusion: ESCAPE-NET will complement ongoing efforts on SCA outside Europe and within Europe
including the EuReCa project.
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