Mechanism of aromatic compound acylation in Friedel–Krafts reaction

In current work, the mechanism of Friedel–Krafts acylation reaction of aromatic compounds is studied. While producing aromatic ketones, the substrate undergoes the interaction with an acyl chloride in the presence of a catalyst. The reaction is initiated by the formation of donor/acceptor complex. In some scenarios carbonylation as a side, reaction can occur. Current work reviews the synthesis of [2.2]cyclophane according to Crame and Truesdale as an example of acylation application in complex molecules synthesis as well as the reactivity of different aromatic compounds in Friedel–Krafts reactions.