Complexity of Hantavirus, its Traits and Treatment
Description
Hantavirus is also called as orthohantavirus and are singlestranded, enveloped, negative RNA virus [(-) ss RNA viruses]. It was named after Hantan River area in South Korea where its occurrence was observed and was isolated in 1976 by Karl M. Johnson and Ho-Wang Lee. There are many strains of Hantavirus; normally rodents are the carrier of these virus. Various strains carried by different rodent species are familiar to cause various types of illness in human, most remarkably, Hemorrhagic Fever with Renal Syndrome (HFRS) which was identified during the Korean War – and Hantavirus Pulmonary Syndrome (HPS) which was discovered in 1993 outbreak in the Southwestern United States. Serious HFRS causes acute kidney failure, while HPS gets filling lungs with fluid (edema). Mortality rate of HFRS is 1 to 15 percent while HPS is 38 percent. One of the remarkable outbreaks of Hantavirus in United States was observed of various strains at Yosemite National Park in late 2012.
Files
Complexity_of_Hantavirus.pdf
Files
(644.3 kB)
Name | Size | Download all |
---|---|---|
md5:baf4c527324bc537e21c11df6c40a312
|
644.3 kB | Preview Download |
Additional details
Related works
- Is identical to
- https://biomedgrid.com/pdf/AJBSR.MS.ID.000620.pdf (URL)
References
- Orthohantavirus (2018) In Wikipedia, the free encyclopedia.
- Virus (2018) In Wikipedia the free encyclopedia.
- Marshall J B (2013) 8 Historically Terrifying Viruses.
- Singh P, Talwar P, Palaniyandi R (2014) Hantavirus Pulmonary Syndrome (HPS): A Concise Review based on Current Knowledge and Emerging Concept. J App Pharm Sci 4(11): 122-130.
- Guo Y, Wang W, Sun Y, Ma C, Wang X, et al. (2015) Crystal Structure of the Core Region of Hantavirus Nucleocapsid Protein Reveals the Mechanism for Ribonucleoprotein Complex Formation. Journal of Virology 90(2):1048-1061.
- Medicalxpress (2018) Study identifies how hantaviruses infect lung cells.
- Daniel Olal, Oliver Daumke (2016) Structure of the Hantavirus Nucleoprotein Provides Insights into the Mechanism of RNA Encapsidation. Cell Reports.
- Max Delbrück Center for Molecular Medicine in the Helmholtz Association (2016) Structure of a hantavirus protein as a promising model for drug design: X-ray crystallography provides drug template against disease transmitted by small rodents. Science Daily.
- Rebecca Brocato, Matthew Josleyn, John Ballantyne, Pablo Vial, Jay W Hooper (2012) DNA Vaccine-Generated Duck Polyclonal Antibodies as a Postexposure Prophylactic to Prevent Hantavirus Pulmonary Syndrome (HPS). PLoS ONE 7(4): e35996.
- US Army Medical Research Institute of Infectious Diseases (2012) DNA vaccine and duck eggs protect against hantavirus disease. ScienceDaily.
- Josiah Petersen, Mary Jane Drake, Emily A Bruce, Amber M Riblett, Chukwuka A Didigu, et al. (2014) The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus Infection. PLoS Pathogens 10(2).
- PLOS (2014) Cholesterol plays a critical role in hantavirus infection. ScienceDaily.
- Josiah Petersen, Mary Jane Drake, Emily A Bruce, Amber M Riblett, Chukwuka A Didigu, et al. (2014) The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus Infection. PLoS Pathogens 10(2).
- University of Pennsylvania School of Medicine (2014) Could statins be used to fight a deadly viral infection? ScienceDaily.
- Jakob Ettinger, Jorg Hofmann, Martin Enders, Friedemann Tewald, Rainer M Oehme, et al. (2012) Multiple Synchronous Outbreaks of Puumala Virus. Emerging Infectious Diseases 18(9): 1461.
- Charité - Universitätsmedizin Berlin (2012) Molecular signature of hantavirus infection in humans decoded. ScienceDaily