Published September 26, 2015 | Version v1
Journal article Open

2909 Expression of insulin growth factor-1 receptor (IGF-1R) is associated with cancer stem-like cells and tumor microenvironment

Authors/Creators

  • 1. Tartu University Hospital, Department of Radiotherapy and Oncological Therapy, Tartu, Estonia;
  • 2. East-Tallinn Central Hospital, Clinic of Internal Medicine, Tallinn, Estonia;
  • 3. University of Tartu, Faculty of Medicine, Tartu, Estonia
  • 4. Riga Stradinˇs University, Faculty of Medicine, Tartu, Estonia

Description

IGF-1R and its activation sustain cancer growth and progression. Moreover, IGF-1R is necessary for cancer cell stemness which is a key feature for cancer cell renewal. The aim of the study was to assess the IGF-1R expression and its association with CD133+ stem-like cells and tumor microenvironment in one of the most aggressive brain tumors − glioblastoma multiforme (GBM).

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