AN OVERVIEW ON ANALYTICAL PROFILE OF VARENICLINE

Varenicline is a medicinal agent used to treat smoking addiction. Varenicline is first permitted nicotinic receptor partial agonist. Varenicline is an orally administered α₄ andβ₂ nicotinic acetylcholine receptor partial agonist. The present study evaluates the various approaches for analysis of VRC in bulk drug as well as formulated products. A short review characterize the collection and discussion of about more than 23 analytical methods which includes HPLC, UPLC, capillary zone electrophoresis, liquid-chromatography mass-spectroscopy methods (LC-MS)and UV-Spectrophotometry methods implemented for investigation of VRC in pharmaceutical matrix. The proposed review article summarizes different reported methods developed to help researchers in choosing significant parameters for new analytical method of Varenicline.

Keywords: Varenicline; method development; HPLC; capillary electrophoresis