Epigenetic Timer of Cancer-2

epiTOC2.R is an R-script that aims to estimate the mitotic age of a sample profiled genome-wide at the DNA methylation level. It is based on a mitotic clock model where DNA methylation errors occuring during cell-division accrue in the adult stem cell pool of a tissue, allowing tracking of the number of stem-cell divisions. epiTOC2 not only estimates the cumulative number of stem-cell divisions, but also allows the intrinsic rate of stem-cell division per stem-cell per year to be estimated if the chronological age of the sample(s) is known. To run epiTOC2.R, see details within the .R file. Running epiTOC2 requires uploading of a data object, dataETOC2.Rd, as shown in the .R script. This data object contains information regarding the specific CpGs that make up epiTOC2.