p21 does, but p53 does not predict pathological response to preoperative chemoradiotherapy in locally advanced rectal cancer
Creators
- 1. Department of Radiotherapy, Institute for Oncology and Radiology of Serbia, Belgrade, and School of Medicine University of Belgrade, Serbia
- 2. Deepartment of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Belgrade
- 3. Department of Pathology, Institute for Gastrointestinal Diseases, Clinical Center Serbia and School of Medicine University of Belgrade, Serbia
- 4. Department of Medical Oncology, Institute for Oncology and Radiology of Serbia
- 5. Data Center, Institute for Oncology and Radiology of Serbia
- 6. Unit of Digestive Radiology, Center of Radiology and MR, Clinical Center Serbia and School of Medicine University of Belgrade, Serbia
- 7. Department of Surgery, Institute for Gastrointestinal Diseases, Clinical Center Serbia and School of Medicine University of Belgrade, Serbia
Description
PURPOSE: Preoperative chemoradiotherapy (CRT) is the standard treatment option in locally advanced rectal cancer. The tumor response is assessed through the tumor and nodal downstaging and the tumor regression grade. Currently, there is no method to predict tumor response to CRT. We aimed to evaluate whether p21 and p53 expressions could be a reliable predictors of pathological response to CRT.
METHODS: Fifty patients with locally advanced rectal cancer were treated with preoperative radiotherapy combined with mitomycin C and capecitabine. p21 and p53 immunohistochemical staining were performed on pretreatment biopsies and the results were compared with tumor regression according to grading systems by Dworak (TRG grades) and by Wheeler (RCRG grades).
RESULTS: Testing RCRG grades in relation to p21 expression showed statistically significant difference (p=0.021). RCRG 3 (poor response) was more frequent in the group of patients with low p21. According to Dworak, grade 4 (complete regression) was more frequent in the group of patients with positive p21 expression (p=0.032). Significant difference in p21 expression in grade 4 group compared with all other grade groups was also found (p=0.007). Patients with immune expression of p21 had significantly higher percentage of complete regression in comparison to the patients with low expression of p21. We haven't found any correlation between p53 expression and histopathological (HP) as well as regression grades.
CONCLUSION: According to both grading systems, our results suggest that p53 expression does not, but p21 expression does predict pathological response to preoperative CRT.
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p21 does, but p53 does not predict pathological response to preoperative chemoradiotherapy in locally advanced rectal cancer.pdf
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Additional details
Related works
- Has part
- 1107-0625 (ISSN)
- 2241-6293 (ISSN)
- Is identical to
- 29332339 (PMID)
Funding
- Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors 41026
- Ministry of Education, Science and Technological Development
- The role of preoperative staging, determining prognostic and therapeutic markers, objectivization of functional results in the decision on the strategy of treatment of the rectal cancer with the aim to improve oncological treatment results and the quality 41033
- Ministry of Education, Science and Technological Development