Can date fruits and 7dates replace iron tablets in increasing hemoglobin levels?
Creators
- 1. Akademi Kebidanan Bina Husada Tangerang
- 2. Akademi Kebidanan Bunda Auni, Bogor
Description
Background. Iron suplement programs, as an approach to overcoming anemia, indicate positive impact although many studies have also noted varying levels of success or even a failure. The known and commonly acknowledged side effect of iron supplements, such as constipation, causes a tendency for patients to stop consuming these supplements.
Aim: To examine hemoglobin level and bowel movement differences resulting from an iron suplement program of the government program as well as consumption of the date fruits, and two common products freely available to the Indonesian consumers.
Method. This study is a pilot randomized controlled trial with four groups consist of three treatment groups and one control group. Respondents were anemia adolescent girls with inclusive but not exclusive criteria. 40 respondents were selected using random permutated blocks. Intervention was done for 30 days with weekly assessments. Data analysis used Friedman Test, Wilcoxon Signed Rank and Multiple Linear Regression test.
Results. There is a significant hemoglobin difference before and after intervention on the four groups. The differences seen in week 1, 2, 3, then tends to decline. Strong, significant correlation is found in treatment with hemoglobin and defecation duration (week 4) and bowel problems (week 2, 3, 4); feeding frequency and menstruation with hemoglobin (week 1); feeding frequency and defecation duration (week 2); water intake and defecation duration (week 4). Multiple linear regression analysis results in regression equation and participants’ prediction towards dependent variables. There is a positive, significant relationship between treatment (week 2, 3) and bowel problems, water intake (week 4) and defecation duration.
Conclusion. Dates can be used instead of iron tablets and 7dates can be used as a companion iron tablets.
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References
- AbouZahr, C. (2003). Global burden of maternal death and disability. Br Med Bull. 67(1-11):1-11. [DOI: 0.1093/bmb/ldg015] Retrieved from https://academic.oup.com/bmb/article/67/1/1/330397
- Agarwal, KN et al. (2003). Anemia prophylaxis in adolescent school girls by weekly or daily iron-folate supplementation. Indian Pediatr. 40(4):296-301. Retrieved from https://indianpediatrics.net/apr2003/apr-296-301.htm
- Agbon, AN et al. (2014). Toxicological evaluation of oral administration of Phoenix dactylifera L. fruit extract on the histology of the liver and kidney of Wistar rats. Int J Anim Vet Adv. 6(4):122-9 Retrieved from http://maxwellsci.com/print/ijava/v6--9.pdf
- Ahn, E et al. (2004). Iron bioavailability in prenatal multivitamin supplements with separated and combined iron and calcium. J Obstet Gynaecol Can. 26(9):809-13. [DOI:10.1016/S701-2163(16)30153-0]. Retrieved from https://www.jogc.com/article/S1701-2163(16)-0/pdf
- AlDallal, S. (2016). Iron deficiency anemia: a short review. J Immunooncol. 2(1):1-6. Retrieved from https://www.omicsonline.org/open-access/iron-deficiency-anaemia-a-short-review-.php?aid=79233
- Al-Farsi, M et al. (2005). Comparison of antioxidant activity, anthocyanins, carotenoids, and phenolics of three native fresh and sun-dried date (Phoenix dactylifera L.) varieties grown in Oman. J Agric Food Chem. 53(19):7592-9. Retrieved from https://pubs.acs.org/doi/abs/10.1021/jf050579q
- Al-Farsi, MA & Lee, CY. (2008). Nutritional and functional properties of dates: a review. Crit Rev Food Sci Nutr. 48(10):877-87. [DOI: 10.1080/10408390701724264]. Retrieved from https://www.tandfonline.com/doi/abs/10.1080/
- Allen, LH. (2000). Anemia and iron deficiency: effects on pregnancy outcome. Am J Clin Nutr. 71(5):1280S–4S. [DOI: 10.093/ajcn/71.5.s] Retrieved from https://academic.oup.com/ajcn/article/71/5/S/4729385
- Allen, LH. (2002). Iron supplements: scientific issues concerning efficacy and implications for research and programs. J Nutr. 132:813S–9S. Retrieved from https://academic.oup.com/jn/article/132/4/813S/4687233
- Al-shahib, W & Marshall, RJ. (2003). The fruit of the date palm: its possible use as the best food for the future? Int J Food Sci Nutr. 54(4):247-59. [DOI: 10.1080/09637480120091982] Retrieved from https://www.tandfonline.com/doi/abs/10.1080/
- Al‐Shahib, W & Marshall, RJ. (2002). Dietary fibre content of dates from 13 varieties of date palm Phoenix dactylifera L. Int J Food Sci Tech. 37(6):719-21. [DOI: 10.1046/j.365-2621.002.00615.x].
- Anderson, AS. (1986). Dietary factors in the aetiology and treatment of constipation during pregnancy. Br J Obstet Gynaecol. 93:245–9.
- Assirey, EAR. (2015). Nutritional composition of fruit of 10 date palm (Phoenix dactylifera L.) cultivars grown in Saudi Arabia. J Taibah Univ Sci. 9:75–9. Retrieved from https://ac.els-cdn.com/S1658365514000703/1-s2.0-S-main.pdf?_tid=b0ec0f03-14fd-47fb-93ce-196ccbbcc49a&acdnat=1528629511_e4d120cd8474a89a6458c17d5c701fea
- Baranwal, AK & Singhi, SC. (2003). Acute iron poisoning: management guidelines. Indian Pediatrics. 40(6):534-40. Retrieved from https://www.researchgate.net/profile/Arun_Baranwal/publication/10692032_Acute_iron_poisoning_Management_guidelines/links/53fdf9a70cf2dca800042a65/Acute-iron-poisoning-Management-guidelines.pdf
- Barrett, JA et al. (1989). Anal function in geriatric patients with faecal incontinence. Gut BMJ. 30(9):1244-51. Retrieved from http://gut.bmj.com/content/gutjnl/30/9/.full.pdf
- Beaton, GH & McCabe, GP. (1999). Efficacy of intermittent iron supplementation in the control of iron deficiency anaemia in developing countries: an analysis of experience. Ottawa, Canada: The Micronutrient Initiative. Retrieved from https://idl-bnc-idrc.dspacedirect.org/bitstream/handle/10625/29662/117067.pdf?sequence=3
- Biglari, F et al. (2008). Antioxidant activity and phenolic content of various date palm (Phoenix dactylifera) fruits from Iran. Food Chemistry. 107:1636–41 Retrieved from https://www.sciencedirect.com/science/article/pii/S0308814607010552
- Borchani, C et al. (2010). Chemical properties of 11 date cultivars and their corresponding fiber extracts. African J Biotechnol. 9(26):4096-105. [DOI: 10.5897/AJB09.1497] Retrieved from https://www.academicjournals.org/article/article1380810378_Borchani%20et%20al.pdf
- Bukhari. (2001). Shahih al-Bukhari, volume 007, book 065, hadith number 356. Beirut: Dar Thauq an Najah. Retrieved from https://muflihun.com/bukhari/65/356 and http://www.hadithcollection.com/sahihbukhari/98-Sahih%20Bukhari%20Book%2065.%20Food,%20Meals/6409-sahih-bukhari-volume-007-book-065-hadith-number-356.html
- Burton-Freeman, B. (2000). Dietary fiber and energy regulation. J Nutr. 130(2):272S–5S. [DOI:10.1093/jn/130.2.272S] Retrieved from https://academic.oup.com/jn/article/130/2/272S/4686350
- Camaschella, C. (2015). Iron-deficiency anemia. N Engl J Med. 372(19):1832-43. Retrieved from http://legeforeningen.no/PageFiles/214782/2015CamaschellaNEJM%20Iron-def%20anemia.pdf
- Casgrain, A et al. (2012). Effect of iron intake on iron status: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 96(4):768–80. Retrieved from https://academic.oup.com/ajcn/article/96/4//4576856
- Cook, JD & Reddy, MB. (1995). Efficacy of weekly compared with daily iron supplementation. Am J Clin Nutr. 62(1):117–20. [DOI: 10.1093/ajcn/62.1.117].
- Cullen, G & O'Donoghue, D. (2007). Constipation and pregnancy. Best Pract Res Clin Gastroenterol. 21(5):807–18. [DOI: 10.1016/j.bpg.2007.05.005] Retrieved from https://www.sciencedirect.com/science/article/pii/S1521691807000595
- Derbyshire, E et al. (2006). Diet, physical inactivity and the prevalence of constipation throughout and after pregnancy. Matern Child Nutr. 2(3):127–34. [DOI: 10.1111/j.740-8709.2006.00061.x] Retrieved from https://www.researchgate.net/profile/Vassiliki_Costarelli/publication/235450087_Dietary_intake_physical_inactivity_and_prevelance_of_constipation_during_and_after_pregnancy/links/0deec523015be91f26000000.pdf
- Deshmukh, PR et al. (2008). Effectiveness of weekly supplementation of iron to control anaemia among adolescent girls of Nashik, Maharashtra, India. J Health Popul Nutr. 26(1):74-8. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740684/pdf/jhpn0026-0074.pdf
- Dukas, L et al. (2003). Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women. AJG. 98(8):1790–6. [DOI: 10.111/j.572-0241.2003.07591.x] Retrieved from http://mccordresearch.com/sites/default/files/pdf/Prebiotic-Fiber/Fiber%20and%20Constipation.pdf
- El-Refaey, H & Rodeck, C. (2003). Post-partum haemorrhage: definitions, medical and surgical management. A time for change. Br Med Bull. 67:205-17. Retrieved from https://academic.oup.com/bmb/article/67/1//330398
- El-Sohaimy, SA & Hafez, EE. (2010). Biochemical and nutritional characterizations of date palm fruits (Phoenix dactylifera L.). JASR. 6(8):1060-7. Retrieved from https://www.researchgate.net/publication/234027076_Biochemical_and_Nutritional_Characterizations_of_Date_Palm_Fruits_Phoenix_dactylifera_L
- El-Zoghbi, M. (1994). Biochemical changes in some tropical fruits during ripening. Food Chem. 49(1):33-7. [DOI: 10.1016/0308-8146(94)90229-1] Retrieved from https://www.sciencedirect.com/science/article/pii/0308814694902291
- Fairweather-Tait, SJ et al. (1992). Riboflavin deficiency and iron absorption in adult Gambian men. Ann Nutr Metab. 36(1):34–40. [DOI: 10.1159/000177696].
- Fawzi, WW et al. (2007). Multivitamin supplementation improves hematologic status in HIV-infected women and their children in Tanzania. Am J Clin Nutr. 85(5):1335–43. [DOI: 10.093/ajcn/85.5].
- Haeri, S & Dildy, GA. (2012). Maternal mortality from hemorrhage. Semin Perinatol. 36(1):48-55. Retrieved from https://www.seminperinat.com/article/S0146-005(11)00156-X/pdf
- Haider, BA et al. (2013). Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. BMJ. 346:1-19. [DOI: 10.1136/bmj.f3443] Retrieved from https://www.bmj.com/content/bmj/346/bmj.f.full.pdf
- Hentze, MW et al. (2010). Review two to Tango: regulation of mammalian iron metabolism. Cell. 142(1):24-38. [DOI: 10.1016/j.cell.2010.06.028] Retrieved from https://ac.els-cdn.com/S009286741000718X/1-s2.0-SX-main.pdf?_tid=3a612389-47be-422b-9e0d-dad3be08f13f&acdnat=1528603880_91ff6f066eeb4f34d7e470a9b6807241
- Hodges, RE et al (1978). Hematopoietic studies in vitamin A deficiency. Am J Clin Nutr. 31(5):876–85. [DOI:10.1093/ajcn/31.5.876] Retrieved from https://academic.oup.com/ajcn/article/31/5/876/4650239
- Hyder, SMZ et al. (2002). Do side-effects reduce compliance to iron supplementation? a study of daily- and weekly-dose regimens in pregnancy. J Health Popul Nutr. 20(2):175-9. Retrieved from http://dspace.icddrb.org/jspui/bitstream/123456789/123/1/2002-JHealthPoulNutr-175-Hyder.pdf
- Indrayani et al. (2018). How do Muslims consume dates?. PJMHS. 12 (4): 1732-1743. [DOI: http://doi.org/10.5281/zenodo.2586225]. Retrieved from http://www.pjmhsonline.com/2018/oct_dec/pdf/1732.pdf
- Ismail, B et al. (2006). Date consumption and dietary significance in the United Arab Emirates. J Sci Food Agric. 86:1196-201. [DOI:10.002/jsfa.2467] Retrieved from https://onlinelibrary.wiley.com/doi/full/10.1002/jsfa.2467
- Jewell, D & Young, G. (2012). Interventions for treating constipation in pregnancy (review). Interventions for treating constipation in pregnancy. Cochrane Database of Systematic Reviews. 2012(2):Art. No.: CD001142. [DOI: 10.1002/14651858.CD001142] Retrieved from http://cochranelibrary-wiley.com/doi/10.1002/.CD001142/full
- Khan, KS et al. (2006). WHO analysis of causes of maternal death: a systematic review. Lancet. 367(9516):1066–74. Retrieved from http://www.hpc4.go.th/director/data/region/WHO_MMR.pdf
- Kollef, MH & Schachter, DT. (1991). Acute pulmonary embolism triggered by the act of defecation. Chest. 99(2):373–6. [DOI:10.1378/chest.99.2.373].
- Kordi, M et al. (2014). The effect of late-pregnancy consumption of date fruit on cervical ripening in nulliparous women. J Midwifery Reprod Health. 2(3):150-6 [DOI: 10.22038/jmrh.2014.2772] Retrieved from http://jmrh.mums.ac.ir/article_2772_b142d1addcd29393341f33980192b552.pdf
- Kurz, KM & Galloway, R. (2000). Improving adolescent iron status before childbearing. J Nutr. 130(2):437S-9S. [DOI: 10.1093/jn/130.2.437S] Retrieved from https://academic.oup.com/jn/article/130/2/437S/4686452
- Layrisse, M et al. (1998). Vitamin A reduces the inhibition of iron absorption by phytates and polyphenols. Food Nutr Bull. 19(1):3-5. Retrieved from http://journals.sagepub.com/doi/pdf/10.1177/156482659801900101
- Lederle, FA. (1995). Epidemiology of constipation in elderly patients: drug-utilisation and cost-containment strategies. Drugs Aging. 6(6):465–9. Retrieved from https://link.springer.com/article/10.2165/00002512-199506060-00006
- Ma, AG et al. (2008). Retinol and riboflavin supplementation decreases the prevalence of anemia in Chinese pregnant women taking iron and folic acid supplements. J Nutr. 138:1946–50, 2008. Retrieved from https://academic.oup.com/jn/article/138/10/1946/4670060
- Mariyam, P & Mary, V. (2015). Nutritional analysis (macronutrients, potassium, and iron content) of four palm date varieties (Phoenix dactylifera L.) and study of consumption pattern among Muslim and Maharashtrian community. J Food Processing Beverages. 3(1):1-9 Retrieved from http://www.avensonline.org/wp-content/uploads/JFPB-2332-4104-03-0011.pdf
- Marlett, JA et al. (2002). Position of the American Dietetic Association: Health implications of dietary fiber. J Am Dietet Assoc. 102(7):993–1000. [DOI: 10.16/S0002-8223(02)90228-2] Retrieved from https://jandonline.org/article/S0002-8223(02)-2/pdf
- Marshall, K et al. (1998). Incidence of urinary incontinence and constipation during pregnancy and postpartum: survey of current findings at the Rotunda lying-in hospital. Br J Obstet Gynaecol. 105:400-2. Retrieved from https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/j.471-0528.1998.tb10123.x
- Maskey, M et al. (2014). Anemia in pregnancy and its associated factors: a study from Eastern Nepal. Nepal J Epidemiol. 4(4):386-92. [DOI: 10.3126/nje.v4i4.11358] Retrieved from https://www.nepjol.info/index.php/NJE/article/view//9205
- Meier, PR, Nickerson HJ, Olson KA, Berg RL, Meyer JA. (2003). Prevention of iron deficiency anemia in adolescent and adult pregnancies. Clin Med Res. 1(1):29–36. Retrieved from http://www.clinmedres.org/content/1/1/29.full.pdf+html
- Miller, JL. (2013). Iron deficiency anemia: a common and curable disease. Cold Spring Harb Perspect Med. 3(7):1-14. Retrieved from http://perspectivesinmedicine.cshlp.org/content/3/7/a011866.full.pdf+html
- Milman, N et al. (2006). Side effects of oral iron prophylaxis in pregnancy – myth or reality? Acta Haematol. 115:115:53-57. [DOI: 10.1159/000089466].
- Mohamed, AE. (2000). Trace element levels in some kinds of dates. Food Chem. 70(1):9-12 [DOI: 10.1016/S0308-8146(99)00232-0].
- Mousa, HA & Walkinshaw, S. (2001). Major postpartum haemorrhage. Curr Opin Obstet Gynecol. 13(6):595-603. [PMID: 11707663].
- Müller-Lissner, SA. (1988). Effect of wheat bran on weight of stool and gastrointestinal transit time: a meta analysis. Br Med J (Clin Res Ed). 296(6622):615–7. [PMCID: PMC2545244] [PMID: 832033] Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC/pdf/bmj00274-0031.pdf
- Müller-Lissner, S. (2002). General geriatrics and gastroenterology: constipation and faecal incontinence. Best Pract Res Clin Gastroenterol. 16(1):115-33. [DOI: 10.1053/bega.2002.0269].
- Muñoz, EC et al. (2000). Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers. Am J Clin Nutr. 71(3):789–94. [DOI: 10.1093/ajcn/71.3.789]. Retrieved from https://academic.oup.com/ajcn/article/71/3/789/4729207
- Muslimatun, S et al. (2001). Weekly supplementation with iron and vitamin A during pregnancy increases hemoglobin concentration but decreases serum ferritin concentration in Indonesian pregnant women. J Nutr. 131(1):85–90 [DOI: 10.1093/jn/131.1.85]. Retrieved from https://academic.oup.com/jn/article/131/1/85/4686571
- Myhara, RM et al. (1999). The composition of maturing Omani dates. J Sci Food Agric. 79(11):1345-50. [DOI: 10.1002/(SICI)1097-0010(199908)79:11<1345::AID-JSFA366>3.0.CO;2-V].
- Norton, C. (2006). Constipation in older patients: effects on quality of life. Br J Nurs. 15(4):188-92. [DOI: 10.12968/bjon.2006.15.4.20542].
- Norton, C. (2004). Nurses, bowel continence, stigma and taboos. J Wound Ostomy Continence Nurs. 31(2):85-94.
- Norton, C. (1996). The causes and nursing management of constipation. Br J Nurs. 5(20):1252–8. [DOI: 10.12968/bjon.1996.5.20.1252].
- Olenmark, M et al. (1987). Fatal iron intoxication in late pregnancy. J Toxicol: Clin Toxicol. 25(4):347-59. [DOI: 10.3109/15563658708992638]. Retrieved from https://www.tandfonline.com/doi/abs/10.3109/
- Ononge, S et al. (2014). Haemoglobin status and predictors of anaemia among pregnant women in Mpigi, Uganda. BMC Res Notes. 7(1):712. Retrieved from https://bmcresnotes.biomedcentral.com/track/pdf/10.1186/756-0500-7-712
- Onuh, SN et al. (2012). Haemopoietic activity and effect of crude fruit extracts of Phoenix dactylifera on peripheral blood parameters. Int J Biol Med Res. 3(2):1720-3 Retrieved from https://www.biomedscidirect.com/journalfiles/IJBMRF2011470/haemopoietic_activity_and_effect_of_crude_fruit_extract_of_phoenix_dactylifera_on_peripheral_blood_parameters.pdf
- Pallarès, I et al. (1993). Effect of iron deficiency on the digestive utilization of iron, phosphorus, calcium and magnesium in rats. Br J Nutr. 70:609-20. Retrieved from https://pdfs.semanticscholar.org/a0ad/ff93e9e51cc964b6afc7525a59e9e4c0e36a.pdf?_ga=2.63231847.971562518.1528626651-29673584.376232
- Panth, M et al. (1990). Effect of vitamin A supplementation on haemoglobin and vitamin A levels during pregnancy. Br J Nutr. 64(2):351-8. [DOI: 10.1079/BJN19900037]. Retrieved from https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6B427718612384D5B2FE851F72016930/S0007114590001131a.pdf/effect_of_vitamin_a_supplementation_on_haemoglobin_and_vitamin_a_levels_during_pregnancy.pdf
- Powers, HJ et al. (1985). Haematological response to supplements of iron and riboflavin to pregnant and lactating women in rural Gambia. Hum Nutr Clin Nutr. Mar 39(2):117-29 Retrieved from https://www.researchgate.net/publication/19143205_Haematological_response_to_supplements_of_iron_and_riboflavin_to_pregnant_and_lactating_women_in_rural_Gambia
- Powers, HJ et al. (1991). Riboflavin deficiency in the rat: effects on iron utilization and loss. Br J Nutr. 65(3):487-96. [DOI: 10.1079/BJN19910107]. Retrieved from https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/riboflavin-deficiency-in-the-rat-effects-on-iron-utilization-and-loss/28E9AA7CB41F0C1F28B781DF4BB46677
- Roektiningroem, E & Hastuti, PW. (May 2016). Seed's viability of two types of dates (Phoenix dactilyfera L.) from fruit in Indonesian Market. Proceeding of 3rd International Conference on Research, Implementation and Education of Mathematics and Science; Yogyakarta, Indonesia: Universitas Negeri Yogyakarta. Retrieved from http://seminar.uny.ac.id/icriems/sites/seminar.uny.ac.id.icriems/files/prosiding/B-05.pdf
- Roodenburg, AJC et al. (1994). Comparison between time-dependent changes in iron metabolism of rats as induced by marginal deficiency of either vitamin A or iron. Br J Nutr. 71(5):687-99. [DOI: 10.1079/BJN19940176].
- Rosado, JL et al. (2010). Efficacy of different strategies to treat anemia in children: a randomized clinical trial. Nutr J. 9(1):40-9 [DOI: 10.1186/475-2891-9-40]. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955680/
- Rosales, FJ et al. (1999). Iron deficiency in young rats alters the distribution of vitamin A between plasma and liver and between hepatic retinol and retinyl esters. J Nutr. 129(6):1223–8. [DOI: 10.093/jn/129.6]. Retrieved from https://academic.oup.com/jn/article/129/6//4721925
- Sawaya, WN et al. (1982). Growth and compositional changes during the various developmental stages of some Saudi Arabian date cultivars. J Food Sci. 47(5):1489-92. [DOI: 10.111/j.365-2621.1982.tb04967.x]. Retrieved from https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2621.1982.tb.x
- Snooks, SJ et al. (1985). Damage to the innervation of the pelvic floor musculature in chronic constipation. Gastroenterology. 89(5):977–81. Retrieved from https://www.gastrojournal.org/article/0016-5085(85)90196-9/pdf
- Spence‐Jones, C et al. (1994). Bowel dysfunction: a pathogenic factor in uterovaginal prolapse and urinary stress incontinence. Br J Obstet Gynaecol. 101(2):147-52. [DOI: 10.1111/j.471-0528.1994.tb13081.x].
- Suharno, D et al. (1993). Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in West Java, Indonesia. Lancet. 342(8883):1325-8. [DOI: 10.016/0140-6736(93)92246-P] Retrieved from https://www.sciencedirect.com/science/article/pii/014067369392246P
- Suprapto, B et al. (2002). Effect of low‐dosage vitamin A and riboflavin on iron‐folate supplementation in anaemic pregnant women. Asia Pacific J Clin Nutr. 11(4):263–7. [DOI: 10.1046/j.440-6047.2002.00310.x].
- Thakur, K et al. (2016). Riboflavin and health: A review of recent human research. Critical Rev Food Sci Nutr. 57(17):3650-60. [DOI: 10.1080/10408398.2016.1145104]. Retrieved from https://www.researchgate.net/publication/299509825_Riboflavin_and_health_A_review_of_recent_human_research
- Schultink, W et al. (1995). Effect of daily vs twice weekly Indonesian preschool children iron supplementation with low iron status. Am J Clin Nutr. 61(1):111–5. [DOI: 10.1093/ajcn/61.1.111].
- Tang, N et al. (2015). Antioxidant and anti-anemia activity of heme iron obtained from bovine hemoglobin. Food Sci Biotechnol. 24(2):pp 635–42. [DOI: 10.1007/s10068-015-0083-2]. Retrieved from https://link.springer.com/article/10.1007/s-015-0083-2
- Toteja, GS et al. (2006). Prevalence of anemia among pregnant women and adolescent girls in 16 districts of India. Food Nutr Bull. 27(4):311-5.
- Vazquez, JC. (2010). Constipation, haemorrhoids, and heartburn in pregnancy. BMJ Clin Evid. 08:1411-28. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217736/
- Williams, CL et al. (1995). A new recommendation for dietary fiber in childhood. Pediatrics. 96(5):985-8. Retrieved from http://pediatrics.aappublications.org/content/pediatrics/96/5/.full.pdf
- Yates, CA et al. (2003). Absence of luminal riboflavin disturbs early postnatal development of the gastrointestinal tract. Dig Dis Sci. 48(6):1159–64 Retrieved from https://link.springer.com/article/10.023/A:1023785200638
- Youssef, HEE-D & Khedr AA. (2015). Effect of black dates on iron deficiency anemia of orphanage children. Alex J Agric Res. 60(3):183-91. Retrieved from http://agr.p.alexu.edu.eg/Data/Sites/1/pdffiles/%D8%A7%D9%84%D9%85%D8%B9%D8%AF%D9%84%20%D8%A7E%D9%84%D8%A3%D9%88%D9%84%203202.pdf
- Youssef, NN et al. (2005). Chronic childhood constipation is associated with impaired quality of life: a case-controlled study. JPGN. 41(1):56-60. [DOI: 10.1097/01.mpg.0000167500.34236.6a].
- Zavaleta, N et al. (2000). Efficacy and acceptability of two iron supplementation schedules in adolescent school girls in Lima, Peru. J Nutr. 130(2):462S–4S. [DOI: 10.1093/jn/130.2.462S] Retrieved from https://academic.oup.com/jn/article/130/2/462S/4686483
- Zygmunt, M et al. (2003). Local and systemic tolerability of magnesium sulphate for tocolysis. Eur J Obstet Gynecol Reprod Biol. 107(2):168–75. [DOI: 10.1016/S0301-2115(02)00368-8].
- Zen, ATH et al. (2013). The effect of date (Phoenix dactylifera) juice on haemoglobin level an experimental study in iron supplemented rats. Sains Medika. 5(1):17-9 Retrieved from http://jurnal.unissula.ac.id/index.php/sainsmedika/article/viewFile/359/298