FORMULATION AND EVALUATION OF CHRONOMODULATED DRUG DELIVERY OF NISOLDIPINE

The aim of present study was to formulate and evaluate oral multiparticulate pulsatile release of nisoldipine based on chronophamaceutical approach for the treatment of hypertension. In the present study the immediate release tablets were prepared by direct compression by using various proportions of different superdisintegrants. The optimized core tablets were then coated with pH sensitive polymer Eudragit- L100. To achieve the desired dissolution profile, the coated tablets were evaluated for hardness, thickness, friability, weight variation, drug content, and disintegration time and in-vitro drug release. In-vitro drug release was found to be 98 % from coated tablets in 15 min after 7 hrs lag time. FT-IR spectra revealed that there is no chemical incompatibility between the drug and other excipients. Scanning electron micrograph of optimized tablet shown that the thickness level in the coating. The results concluded the programmable pulsatile release has been achieved from coated tablets after a lag time of 5 hrs, which is consistent with the demands of the chronotherapeutic drug delivery and increasing bioavailability.