CIC bioGUNE
Published November 24, 2017 | Version Peer-reviewed version
Journal article Open

Glycans in Infectious Diseases. A molecular recognition perspective

Creators

Description

The importance of glycans in infection processes has been demonstrated during the past few years. Indeed, it is today a hot topic with diverse branches and perspectives. The field is therefore attracting increased attention and it is expected that will provide spectacular developments. In this non-exhaustive review, we have focused on the molecular recognition aspects that involve the participation of glycans in different infection processes of paramount importance, with special attention to the applications of NMR spectroscopy and other biophysical techniques. The host-pathogen interactions arise from molecular recognition events between carbohydrates and the molecular receptors. Indeed, this interaction may take place in either direction.  Either glycans on the pathogen and lectins on the host cell or viceversa. In the following examples, we will provide examples of both cases.

Notes

We thank financial support from the Marie Curie Initial Training Networks TOLLerant and GlycoVAX (EU), grant CTQ2015-64597-C2-1-P of MINECO (Spain), a FPU fellowship to P.V. and the Juan de la Cierva and Ramon y Cajal contracts to A.G. and A.A., respectively. We also thank CIC bioGUNE for continuous funding.

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Additional details

Funding

European Commission
TOLLerant - Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach. 642157
European Commission
GLYCOVAX - A training network for the rational design of the next generation of well-defined glycoconjugate vaccines 675671