Friend or Foe? Chloride Patterning in Halophytes

In this opinion article, we challenge the traditional view that breeding for reduced Cl^- uptake would benefit plant salinity tolerance. A negative correlation between shoot Cl^- concentration and plant biomass does not hold for halophytes - naturally salt tolerant species. We argue that, under physiologically relevant conditions, Cl^- uptake requires plants to invest metabolic energy, and that the poor selectivity of Cl^--transporting proteins may explain the reported negative correlation between Cl^- accumulation and crop salinity tolerance. We propose a new paradigm: salinity tolerance could be achieved by improving the selectivity of some of the broadly selective anion-transporting proteins (e.g., for NO₃^->Cl^-), alongside tight control of Cl^- uptake, rather than targeting traits mediating its efflux from the root.