SYNTHESIS, ANTITUBERCULAR AND ANTIBACTERIAL ACTIVITIES OF NOVEL N'-(SUBSTITUTED)-2-(2,5-DIMETHYL-1H-PYRROL-1-YL)PHENYL)BENZAMIDE DERIVATIVES

Novel series of pyrrolylbenzamide derivatives were synthesized with an aim to combat the increasing anti-tubercular resistance and to develop more potent anti-tubercular agents with reasonably less side effect. Herein, we synthesized a series of substituted 2-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)benzamides (3a-f) by reacting different substituted aromatic acids with 2-(2,5-dimethyl-1H-pyrrol-1-yl)aniline (2) by using HBTU as a coupling agent, DIEA as a catalyst and DMF as a solvent. Structures of all the newly synthesized compounds were established by spectral analysis viz., IR, 1H NMR, 13C NMR and Mass. Further they were tested for their anti-tubercular and antibacterial activities and compounds showed moderate to good activity.