Gastroprotective effects of the fatty acid esters and ethanol-amides synthesised from extra-virgin Oleum Olivae - on pharmacological induced ulcers and gastric secretion on rat

Bioactive foods are gaining increasing attention due to the scientific evidences related to the correlations between diet and health status. The mediterranean diet is associated with reduced risk of developing chronic degenerative disorders such as cardiovascular diseases, type 2 diabetes and cancer, it can improve diseases symptoms in inflammatory degenerative diseases, acting both at local and systemic levels. The role of the extra virgin olive oil (EVOO) is essential, many studies showed the importance of a rich in olive oil diet. The role of polyfenols and free fatty acids in the EVOO is extensive investigated, corelating the action of the fatty acids and the endogenous endocannabinoid system. In this purpose, we measured the protective effect of the esthers and ethanolamides of the fatty acids from extra-virgin Oleum Olivae on the experimental gastric ulcers and on the gastric secretion on rat. The therapy with the ethanolamides of the fatty acids in the presence of indometacin reduced the number of ulcers with 89.96% compared with indometacin and methylic esthers, reduced with 53.61%. The gastric acidity of the animals treated with indometacin and ethanolamides of the fatty acids decreased with 60.66% compared with the animals treated with indometacin only, and with 38.11% for the ethylic esters and indometacin; the ethanolamides of the fatty acids from the extra-virgin Olive oil presented a protective effect in the ulcers induced by indometacin.