Published August 31, 2018 | Version v1
Journal article Open

A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport

Creators

  • 1. Mimetas BV, J.H. Oortweg 19, 2333 CH Leiden, The Netherlands Department of Cell and Chemical Biology, Leiden University Medical Centre, Einthovenweg 20, 2333 ZC Leiden, The Netherlands
  • 2. Mimetas BV, J.H. Oortweg 19, 2333 CH Leiden, The Netherlands
  • 3. Biogen, 225 Binney Street, 02142, Cambridge, MA, USA
  • 4. Mimetas BV, J.H. Oortweg 19, 2333 CH, Leiden, The Netherlands
  • 5. Yamaguchi University Graduate School of Medicine, Minamikogushi, 7558505, Ube, Yamaguchi, Japan

Description

Receptor-mediated transcytosis is one of the major routes for drug delivery of large molecules into the brain. The aim of this study was to develop a novel model of the human blood–brain barrier (BBB) in a high-throughput microfluidic device. This model can be used to assess passage of large biopharmaceuticals, such as therapeutic antibodies, across the BBB.

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Wevers_et_al-2018-Fluids_and_Barriers_of_the_CNS.pdf

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Additional details

Funding

ADAPTED – Alzheimers Disease Apolipoprotein Pathology for Treatment Elucidation and Development - Sofia ref.: 115975 115975
European Commission