Journal article Open Access

Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q10 Preparations in the Treatment of Avascular Necrosis of the Femoral Head

Yasin Emre KAYA

Contact person(s)
Yasin Emre KAYA

Thesis supervisor(s)

Yasin Emre KAYA

Endometrial carcinoma is one of the commonest cancers in woman. E Cadherin, Her2/neu, and P53 had an important role in predicting the prognosis of endometrial carcinoma. The objective is to evaluate expression of E-cadherin, HER2/neu and p53 in Endometrial Carcinoma and to find their relationship with clinicopathological characteristics. Material and Methods: 92 specimens were tested for E- cadherin, HER-2/neu and p53 expression using immunohistochemical analysis. The significance of association of expression of the markers with clinicopathological parameters was assessed. Results: Significant association of E- cadherin overexpression with endometrioid type (P=0.001). While this was not the case as regard HER2 or p53. P53 was significantly related to high grade (P=0.02). There was statistically significant association between myometrial invasion and either E- cadherin expression or P53 (P=0.01, 0.03) respectively. There was significant considerable negative correlation between E- cadherin and p53 expression (P=0.000, co: -0.428). Conclusion: E- cadherin expression is good predictor of the prognosis of endometrial cancer than proliferation marker HER2/neu or p53. Endometrial cancer–specific HER2 IHC testing and scoring guidelines need to be developed in the future to reflect the unique biology and pathogenetic features of these tumors. 

Files (176.2 kB)
Name Size
Kaya.pdf
md5:9ea12407dfa0ffc8740707147cdc9210
176.2 kB Download
  • Akgun FS, Karaarslan N, Yilmaz I, Ozbek H, Caliskan T, Ates O (2018). Systematic Evaluation of Adverse Reactions That May Occur After Injection of Type-A Botulinum Toxin in Patients with Spasmodic Torticollis Admitted to Emergency Department. Merit Res. J. Med. Med. Sci.;6(2): 68-72. Akyuva Y, Karaarslan N, Yilmaz I, Caliskan T, Sirin DY (2018). Will intervertebral disc diseases be prevented by siRNA ormiRNA-based genomic treatment modalities? Merit Res. J. Med. Med. Sci.;6(1):6- 15. Axelsson KF, Nilsson AG, Wedel H, Lundh D, Lorentzon M (2017). Association Between Alendronate Use and Hip Fracture Risk in Older Patients Using Oral Prednisolone.JAMA.;318(2):146-155. Bast A, Haenen GR (1992). The toxicity of antioxidants and their metabolites. Environ. Toxicol. Pharmacol. 2002; 11(3): 251-258. Busse E, Zimmer G, Schopohl B, Kornhuber B (1992). Influence of αlipoicacid on intracellular glutathione in vitroand in vivo. Arzneim - Forsch/DrugRes.; 42: 829-832. Cao F, Liu G, Wang W, Wang B, Wei X, Lu F, Yang F, Kang K, Wang Y, Yang J, Qin K, Zhao D (2017). Combined Treatment with an Anticoagulant and a Vasodilator Prevents SteroidAssociated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability.Biomed. Res. Int.;2017:1624074. Cao X, Zhu L, Song X, Hu Z, Cronan JE (2018). Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on itscognateenzymes. Proc. Natl. Acad. Sci U S A. Jul 24;115(30):E7063-E7072. Chughtai M, Piuzzi NS, Khlopas A, Jones LC, Goodman SB, Mont MA (2017). An evidence-based guide to the treatment of osteonecrosis of the femoral head. Bone Joint J. 99-B(10):1267- 1279. Furlan JC, Gulasingam S, Craven BC. TheHealthEconomics of the spinal cord injury or disease among veterans of war: A systematic review. J. Spinal Cord. Med. 2017; 40(6): 649-664. Glueck CJ, Freiberg RA, Sieve L, Wang P (2005). Enoxaparin prevents progression of stages I and II osteonecrosis of the hip. Clin. Orthop. Related. Res.; 435:164-170. Gonidakis S, Finkel SE, Longo VD. E (2010). colihypoxia-inducible factor ArcAmediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoAsynthetase. Biol. Chem. Oct;391(10):1139-47. Gutteridge JM (1995). Lipid peroxidation and antioxidants as biomarkers of tissued amage. Clin. Chem. 41(12): 1819-1828. Huang YP, Jin HY, Yu HP (2017). Inhibitory effects of alpha-lipoic acid on oxidative stress in therostral ventrolateral medulla in ratswith salt-induced hypertension. Int. J. Mol. Med. Feb;39(2): 430-436. Kalyan S, Huebbe P, Esatbeyoglu T, Niklowitz P, Côté HC, Rimbach G, Kabelitz D (2014). Nitrogen-bisphosphonate therapy is linked to compromised coenzyme Q10 and vitamin E status in postmenopausalwomen. J. Clin. Endocrinol. Metab. Apr;99(4):1307- 13. Kang MH, Lee DK, Kim CW, Song IS, Jun SH (2018). Clinical characteristics and recurrence-related factors of medicationrelated osteonecrosis of the jaw. J. Korean Assoc. Oral Maxillofac Surg.;44(5):225-231. Karaarslan N, Kaya YE, Yilmaz I, Ozbek H, Bilir EB, Kaplan N, Sirin DY, Akyuva Y, Gurbuz MS, Oznam K, Akkaya S, Mutlu CA, Guler O, Ates O, Mahirogullari M (2017). Will it be possible to prevent lumbar degenerative disc diseases in the future by means of vitamin D receptor gene manupulation? Merit Res. J. Med. Med. Sci. 5(10): 500-510. Karaarslana N, Yilmaz I, Akgun FS, Caliskan T, Ozbek H, Ates O (2018). Systematic Evaluation of Desmopressin Applied to the Patients with Aneurysmal Subarachnoid Haemorrhage in thelight of theLiterature.TurkNeurosurg. Apr 9. doi: 10.5137/1019- 5149.JTN.23064-18.1. [Epubahead of print]. Karaarslanb N, Yilmaz I, Ozbek H, Caliskan T, Topuk S, Sirin DY, Ates O (2018). Systematic Evaluation of Promising Clinical Trials-Gene Silencing for the Treatment of Glioblastoma. Turk. Neurosurg. Apr 6. doi: 10.5137/1019-5149.JTN.22467-18.3. [Epubahead of print]. Komurcu E, Oktay M, Kaymaz B, Hatay Golge U, Goksel F, Nusran G (2014). Preventive effects of coenzyme Q10 (CoQ10) on steroidinduced osteonecrosis in rats. Acta. Orthop. Traumatol. Turc. 48(2):217-22. Lu BB, Li KH (2012). Lipoic acid prevents steroid-induced osteonecrosis in rabbits. Rheumatol Int.; 32(6): 1679-83. Lynch JJ Jr, Detwiler TJ, Kane SA, Regan CP (2010). Effect of calcitonin gene-related peptide receptor antagonism on the systemic blood pressure responses to mechanistically diverse vasomodulators in conscious rats.J Cardiovasc. Pharmacol. 56(5):518-25. Mont MA, Carbone JJ, Fairbank AC (1996). Core decompression versus non-operative management for osteonecrosis of the hip.Clin. Orthop. Relat. Res;324:169-178. Packer L, Witt E, Tritschler HJ (1995). α-Lipoicacid as a biologicalantioxidant. Science Direct-Free Radical Biology and Medicine. 19(2):227-250. Shen QW, Zhu MJ, Tong J, Ren J, Du M (2007). Ca2+/calmodulindependent protein kinasekinase is involved in AMP-activated protein kinase activation by alpha-lipoicacid in C2C12 myotubes. Am J Physiol Cell Physiol. Oct;293(4):C1395-403. Sissons HA, Nuovo MA, Steiner GC (1992). Pathology of osteonecrosis of thefemoralhead. A review of experience at the Hospital for Joint Diseases, New York. Skeletal Radiol; 21:229-38. Streeper RS, Henriksen EJ, Jacob S, Hokama JY, Donovan LF, Tritschler HJ (1997). Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol.; 273: E185-E191. Tibullo D, LiVolti G, Giallongo C, Grasso S, Tomassoni D, Anfuso CD, Lupo G, Amenta F, Avola R, Bramanti V (2017). Biochemical and clinical relevance of alphalipoic acid: antioxidant and antiinflammatory activity, molecular pathways and therapeutic potential. Inflamm. Res. Nov;66(11):947-959. Topuk S, Akyuva Y, Karaaslan N, Mutlu CA, Yilmaz I, Isyar M, Sirin DY, Akkaya S, Özbek H, Mahirogullari M (2017). Is it Possible to Treat Osteosarcoma Using Oligonucleotides Confined into Controlled Release Drug Delivery Systems? Curr. Pharm. Biotechnol. 18(6):516-522. Kaya 431 Vietto V, Franco JV, Saenz V, Cytryn D, Chas J, Ciapponi A (2018). Prostanoids for critical limbischaemia.Cochrane Database Syst. Rev. Jan 10;1:CD006544. Wang F, Wang Y, Hu N, Miao X (2016). Risk-Factors, Pathogenesis, And Pharmaceutical Approaches For Treatment Of Steroid-Induced Bone Infarction Of Femoral Head. ActaPol Pharm. May-Jun; 73(3):557-63. Wang J, Kalhor A, Lu S, Crawford R, Ni JD, Xiao Y (2015). iNOS expression and osteocyteapoptosis in idiopathic, non-traumatic osteonecrosis. ActaOrthop. 86(1):134-41. Yilmaz I, Ulugol A (2009). The effect of nitric oxide synthase inhibitors on the development of analgesic tolerance to dipyrone in mice. Int J Neurosci. 119(6): 755-64. Yu X, Zhang D, Chen X, Yang J, Shi L, Pang Q (2018). Effectiveness of various hip preservation treatments for nontraumatic osteonecrosis of the femoral head: A network metaanalysis of randomized controlled trials. J Orthop. Sci. Mar;23(2):356-364.

17
14
views
downloads
All versions This version
Views 1717
Downloads 1414
Data volume 2.5 MB2.5 MB
Unique views 1111
Unique downloads 77

Share

Cite as