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Systematic Review of the Effects of Alpha Lipoic Acid and Ubiquinone / Coenzyme-Q10 Preparations in the Treatment of Avascular Necrosis of the Femoral Head

Yasin Emre KAYA

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Yasin Emre KAYA

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Yasin Emre KAYA

Endometrial carcinoma is one of the commonest cancers in woman. E Cadherin, Her2/neu, and P53 had an important role in predicting the prognosis of endometrial carcinoma. The objective is to evaluate expression of E-cadherin, HER2/neu and p53 in Endometrial Carcinoma and to find their relationship with clinicopathological characteristics. Material and Methods: 92 specimens were tested for E- cadherin, HER-2/neu and p53 expression using immunohistochemical analysis. The significance of association of expression of the markers with clinicopathological parameters was assessed. Results: Significant association of E- cadherin overexpression with endometrioid type (P=0.001). While this was not the case as regard HER2 or p53. P53 was significantly related to high grade (P=0.02). There was statistically significant association between myometrial invasion and either E- cadherin expression or P53 (P=0.01, 0.03) respectively. There was significant considerable negative correlation between E- cadherin and p53 expression (P=0.000, co: -0.428). Conclusion: E- cadherin expression is good predictor of the prognosis of endometrial cancer than proliferation marker HER2/neu or p53. Endometrial cancer–specific HER2 IHC testing and scoring guidelines need to be developed in the future to reflect the unique biology and pathogenetic features of these tumors. 

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  • Akgun FS, Karaarslan N, Yilmaz I, Ozbek H, Caliskan T, Ates O (2018). Systematic Evaluation of Adverse Reactions That May Occur After Injection of Type-A Botulinum Toxin in Patients with Spasmodic Torticollis Admitted to Emergency Department. Merit Res. J. Med. Med. Sci.;6(2): 68-72. Akyuva Y, Karaarslan N, Yilmaz I, Caliskan T, Sirin DY (2018). Will intervertebral disc diseases be prevented by siRNA ormiRNA-based genomic treatment modalities? Merit Res. J. Med. Med. Sci.;6(1):6- 15. Axelsson KF, Nilsson AG, Wedel H, Lundh D, Lorentzon M (2017). Association Between Alendronate Use and Hip Fracture Risk in Older Patients Using Oral Prednisolone.JAMA.;318(2):146-155. Bast A, Haenen GR (1992). The toxicity of antioxidants and their metabolites. Environ. Toxicol. Pharmacol. 2002; 11(3): 251-258. Busse E, Zimmer G, Schopohl B, Kornhuber B (1992). Influence of αlipoicacid on intracellular glutathione in vitroand in vivo. Arzneim - Forsch/DrugRes.; 42: 829-832. Cao F, Liu G, Wang W, Wang B, Wei X, Lu F, Yang F, Kang K, Wang Y, Yang J, Qin K, Zhao D (2017). Combined Treatment with an Anticoagulant and a Vasodilator Prevents SteroidAssociated Osteonecrosis of Rabbit Femoral Heads by Improving Hypercoagulability.Biomed. Res. Int.;2017:1624074. Cao X, Zhu L, Song X, Hu Z, Cronan JE (2018). Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on itscognateenzymes. Proc. Natl. Acad. Sci U S A. Jul 24;115(30):E7063-E7072. Chughtai M, Piuzzi NS, Khlopas A, Jones LC, Goodman SB, Mont MA (2017). An evidence-based guide to the treatment of osteonecrosis of the femoral head. Bone Joint J. 99-B(10):1267- 1279. Furlan JC, Gulasingam S, Craven BC. TheHealthEconomics of the spinal cord injury or disease among veterans of war: A systematic review. J. Spinal Cord. Med. 2017; 40(6): 649-664. Glueck CJ, Freiberg RA, Sieve L, Wang P (2005). Enoxaparin prevents progression of stages I and II osteonecrosis of the hip. Clin. Orthop. Related. Res.; 435:164-170. Gonidakis S, Finkel SE, Longo VD. E (2010). colihypoxia-inducible factor ArcAmediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoAsynthetase. Biol. Chem. Oct;391(10):1139-47. Gutteridge JM (1995). Lipid peroxidation and antioxidants as biomarkers of tissued amage. Clin. Chem. 41(12): 1819-1828. Huang YP, Jin HY, Yu HP (2017). Inhibitory effects of alpha-lipoic acid on oxidative stress in therostral ventrolateral medulla in ratswith salt-induced hypertension. Int. J. Mol. Med. Feb;39(2): 430-436. Kalyan S, Huebbe P, Esatbeyoglu T, Niklowitz P, Côté HC, Rimbach G, Kabelitz D (2014). Nitrogen-bisphosphonate therapy is linked to compromised coenzyme Q10 and vitamin E status in postmenopausalwomen. J. Clin. Endocrinol. Metab. Apr;99(4):1307- 13. Kang MH, Lee DK, Kim CW, Song IS, Jun SH (2018). Clinical characteristics and recurrence-related factors of medicationrelated osteonecrosis of the jaw. J. Korean Assoc. Oral Maxillofac Surg.;44(5):225-231. Karaarslan N, Kaya YE, Yilmaz I, Ozbek H, Bilir EB, Kaplan N, Sirin DY, Akyuva Y, Gurbuz MS, Oznam K, Akkaya S, Mutlu CA, Guler O, Ates O, Mahirogullari M (2017). Will it be possible to prevent lumbar degenerative disc diseases in the future by means of vitamin D receptor gene manupulation? Merit Res. J. Med. Med. Sci. 5(10): 500-510. Karaarslana N, Yilmaz I, Akgun FS, Caliskan T, Ozbek H, Ates O (2018). Systematic Evaluation of Desmopressin Applied to the Patients with Aneurysmal Subarachnoid Haemorrhage in thelight of theLiterature.TurkNeurosurg. Apr 9. doi: 10.5137/1019- 5149.JTN.23064-18.1. [Epubahead of print]. Karaarslanb N, Yilmaz I, Ozbek H, Caliskan T, Topuk S, Sirin DY, Ates O (2018). Systematic Evaluation of Promising Clinical Trials-Gene Silencing for the Treatment of Glioblastoma. Turk. Neurosurg. Apr 6. doi: 10.5137/1019-5149.JTN.22467-18.3. [Epubahead of print]. Komurcu E, Oktay M, Kaymaz B, Hatay Golge U, Goksel F, Nusran G (2014). Preventive effects of coenzyme Q10 (CoQ10) on steroidinduced osteonecrosis in rats. Acta. Orthop. Traumatol. Turc. 48(2):217-22. Lu BB, Li KH (2012). Lipoic acid prevents steroid-induced osteonecrosis in rabbits. Rheumatol Int.; 32(6): 1679-83. Lynch JJ Jr, Detwiler TJ, Kane SA, Regan CP (2010). Effect of calcitonin gene-related peptide receptor antagonism on the systemic blood pressure responses to mechanistically diverse vasomodulators in conscious rats.J Cardiovasc. Pharmacol. 56(5):518-25. Mont MA, Carbone JJ, Fairbank AC (1996). Core decompression versus non-operative management for osteonecrosis of the hip.Clin. Orthop. Relat. Res;324:169-178. Packer L, Witt E, Tritschler HJ (1995). α-Lipoicacid as a biologicalantioxidant. Science Direct-Free Radical Biology and Medicine. 19(2):227-250. Shen QW, Zhu MJ, Tong J, Ren J, Du M (2007). Ca2+/calmodulindependent protein kinasekinase is involved in AMP-activated protein kinase activation by alpha-lipoicacid in C2C12 myotubes. Am J Physiol Cell Physiol. Oct;293(4):C1395-403. Sissons HA, Nuovo MA, Steiner GC (1992). Pathology of osteonecrosis of thefemoralhead. A review of experience at the Hospital for Joint Diseases, New York. Skeletal Radiol; 21:229-38. Streeper RS, Henriksen EJ, Jacob S, Hokama JY, Donovan LF, Tritschler HJ (1997). Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscle. Am J Physiol.; 273: E185-E191. Tibullo D, LiVolti G, Giallongo C, Grasso S, Tomassoni D, Anfuso CD, Lupo G, Amenta F, Avola R, Bramanti V (2017). Biochemical and clinical relevance of alphalipoic acid: antioxidant and antiinflammatory activity, molecular pathways and therapeutic potential. Inflamm. Res. Nov;66(11):947-959. Topuk S, Akyuva Y, Karaaslan N, Mutlu CA, Yilmaz I, Isyar M, Sirin DY, Akkaya S, Özbek H, Mahirogullari M (2017). Is it Possible to Treat Osteosarcoma Using Oligonucleotides Confined into Controlled Release Drug Delivery Systems? Curr. Pharm. Biotechnol. 18(6):516-522. Kaya 431 Vietto V, Franco JV, Saenz V, Cytryn D, Chas J, Ciapponi A (2018). Prostanoids for critical limbischaemia.Cochrane Database Syst. Rev. Jan 10;1:CD006544. Wang F, Wang Y, Hu N, Miao X (2016). Risk-Factors, Pathogenesis, And Pharmaceutical Approaches For Treatment Of Steroid-Induced Bone Infarction Of Femoral Head. ActaPol Pharm. May-Jun; 73(3):557-63. Wang J, Kalhor A, Lu S, Crawford R, Ni JD, Xiao Y (2015). iNOS expression and osteocyteapoptosis in idiopathic, non-traumatic osteonecrosis. ActaOrthop. 86(1):134-41. Yilmaz I, Ulugol A (2009). The effect of nitric oxide synthase inhibitors on the development of analgesic tolerance to dipyrone in mice. Int J Neurosci. 119(6): 755-64. Yu X, Zhang D, Chen X, Yang J, Shi L, Pang Q (2018). Effectiveness of various hip preservation treatments for nontraumatic osteonecrosis of the femoral head: A network metaanalysis of randomized controlled trials. J Orthop. Sci. Mar;23(2):356-364.

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