A PROSPECTIVE CLINICAL RESEARCH TO ASSESS THE CORRELATION BETWEEN ONDANSETRON ANTI-EMETIC EFFECTIVENESS WITH POLYMORPHISM IN (18792A>G)

Objective: This study was to assess the connection of anti-emetic effectiveness of ondansetron with 18792A>G polymorphism in the target gene of 5-hydroxytryptamine type 3 subtype B.

Method: The genetic analysis was accomplished at Jinnah Hospital, Lahore from August 2016 to October 2017). The subjects enlisted were experiencing elective laparoscopic cholecystectomy under general anaesthesia. Every one of the patients was given the enemy of emetic ondansetron (4mg) intravenously 30 minutes before the finish of medical procedure. Inside the initial two hours after the medical procedure, the reaction to ondansetron was noted down. Patients with the grumblings of heaving and the individuals who had no spewing were broke down for 18792A>G polymorphism utilizing polymerase chain response confinement part length polymorphism strategy.

Results: Of the 350 patients, 183 (52%) had protests of heaving and 167 (48%) had no such grievances. In general, 195 (56%) patients had 18792AA genotype, 130 (37%) had genotype AG, and 25 (7%) had GG genotype. No noteworthy affiliation was found between the frequency of retching and the 18792A>G genotypes at 2 hours after the medical procedure (p>0.05).

Conclusion: No relationship of hostile to emetic adequacy of ondansetron with 18792A>G polymorphism in the objective quality of 5-hydroxytryptamine type 3 subtype B was found.

Keywords: 18792A>G, Ondansetron, Polymorphism, Postoperative Nausea Vomiting.