FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE ORAL DISPERSABLE TABLETS

Metformin HCL is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM). It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption and increasing insulin mediated glucose uptake. In the present study an attempt has been made to prepare oral dissolving tablets of Metformin HCL which dissolves fast and easy in the oral cavity with enhanced dissolution rate. The tablets were prepared with two superdisintegrants e.g., Croscarmellose sodium, Sodium Starch Glycolate. The blend was examined for Angle of repose, Bulk density, Tapped density, Compressibility index and Hausners ratio. The tablets were evaluated for hardness, friability, disintegration time, dissolution rate, drug content were found to be within 30 sec. It was concluded that the mouth dissolving tablets with proper hardness, rapidly disintegrating with enhanced dissolution can be made using selected superdisintegrants.